Global Patent Index - EP 1003698 A1

EP 1003698 A1 2000-05-31 - PREPARATION OF GEM-DIHALOALKANES

Title (en)

PREPARATION OF GEM-DIHALOALKANES

Title (de)

HERSTELLUNG VON GEM-DIHALOALKANEN

Title (fr)

PREPARATION DE GEM-DIHALOALCANES

Publication

EP 1003698 A1 (EN)

Application

EP 98940835 A

Priority

  • US 9816562 W
  • US 5532897 P

Abstract (en)

[origin: WO9907658A1] This invention relates to a method of preparing and purifying gem-dihaloalkanes in high yield and with minimal decomposition. The preparation consists essentially of halogenating a ketone with a halogenating agent and then purifying the resulting gem-dihaloalkane by vacuum distillation from the reaction mixture. In one preferred embodiment, 1,1-dichloro-1-cyclopropylethane is prepared and purified in good yield. Certain gem-dihaloalkanes are used as intermediates for the synthesis of novel HIV reverse transcription inhibitors.

IPC 1-7 (main, further and additional classification)

C07C 17/00; C07C 17/38; C07C 19/08

IPC 8 full level (invention and additional information)

C07C 17/18 (2006.01); C07C 17/383 (2006.01)

CPC (invention and additional information)

C07C 17/18 (2013.01); C07C 17/383 (2013.01)

Combination set (CPC)

  1. C07C 17/18 + C07C 22/00
  2. C07C 17/383 + C07C 22/00

Citation (search report)

See references of WO 9907658A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9907658 A1 19990218; CA 2299636 A1 19990218; EP 1003698 A1 20000531

INPADOC legal status


2000-12-20 [18W] WITHDRAWN

- Date of withdrawal: 20001024

2000-07-12 [RIN1] INVENTOR (CORRECTION)

- Inventor name: OWENS, STEPHEN, W.

2000-07-12 [RIN1] INVENTOR (CORRECTION)

- Inventor name: REINEKE, KARL, E.

2000-07-12 [RIN1] INVENTOR (CORRECTION)

- Inventor name: SHIPPLETT, REX, A.

2000-07-12 [RIN1] INVENTOR (CORRECTION)

- Inventor name: TUETING, DAVID, R.

2000-07-12 [RIN1] INVENTOR (CORRECTION)

- Inventor name: WOLTERMANN, CHRISTOPHER, J.

2000-07-12 [RIN1] INVENTOR (CORRECTION)

- Inventor name: SANCHEZ, IGNACIO, H.

2000-05-31 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000301

2000-05-31 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE