Global Patent Index - EP 1003712 A1

EP 1003712 A1 2000-05-31 - ANTHRANILIC ACID ANALOGS

Title (en)

ANTHRANILIC ACID ANALOGS

Title (de)

ANTHRANILSÄUREANALOGA

Title (fr)

ANALOGUES D'ACIDE ANTHRANILIQUE

Publication

EP 1003712 A1 (EN)

Application

EP 98938288 A

Priority

  • US 9816099 W
  • US 90668397 A

Abstract (en)

[origin: WO9907669A1] Compounds of formula (I) wherein: R1, R2, R3, R4, R5, R6, R7 and R8 are, independently, hydrogen, COOR15, halogen, nitro, cyano, C1-10 alkoxy, C1-10 haloalkoxy, sulfonic acid, C1-10 alkylsulfonyl, C6-12 arylsulfonyl, C6-12 aralkylsulfonyl, C1-10 alkylsulfinyl, C6-12 arylsufinyl, C6-12 aralkylsulfinyl, sulfamoyl, C1-10 alkylsulfamido, C6-12 arylsulfamido, C1-10 alkanoyl, C6-12 aryloyl, C6-12 aralkanoyl, amino, C1-10 alkylamino, C2-10 dialkylamino, C6-12 arakylamino, C6-12 arylamino, carboxamido, C1-10 alkylcarboxamido, C6-12 arylcarboxamido, C1-10 haloalkyl, C1-10 alkyl, C2-12 alkenyl, C6-12 aryl, C6-12 aralkyl; with the proviso that at least one of R4 and R5 is COOR15; R9 is hydrogen, C1-10 alkyl, and C1-10 haloalkyl; R10 is hydrogen, C1-10 alkyl, C1-10 haloalkyl, or C2-12 alkylidene; R15 is hydrogen, metal cation, acetylamido, alkoxyacetoyl or a related moiety which delivers the carboxylate in vivo; the dotted line is an optional double bond; with the proviso that when R10 is an alkylidene moiety, the double bond is absent; and W is nitrogen or carbon bearing a hydrogen, or R4, R5 or R6 as hereinbefore defined; or pharmaceutical salts thereof, are useful in the treatment of disorders associated with smooth muscle contraction via potassium channel and chloride channel modulation.

IPC 1-7 (main, further and additional classification)

C07C 233/55; C07D 213/79

IPC 8 full level (invention and additional information)

C07D 213/75 (2006.01); A61K 31/167 (2006.01); A61K 31/196 (2006.01); A61P 9/06 (2006.01); A61P 9/10 (2006.01); A61P 11/06 (2006.01); A61P 13/06 (2006.01); A61P 25/22 (2006.01); A61P 25/28 (2006.01); A61P 43/00 (2006.01); C07C 233/55 (2006.01); C07D 213/79 (2006.01); C07D 213/80 (2006.01)

CPC (invention and additional information)

C07D 213/80 (2013.01); C07C 233/55 (2013.01)

Citation (search report)

See references of WO 9907669A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

EPO simple patent family

WO 9907669 A1 19990218; AU 8684598 A 19990301; BR 9811845 A 20000808; CA 2297412 A1 19990218; CN 1273579 A 20001115; EP 1003712 A1 20000531; JP 2001513526 A 20010904

INPADOC legal status


2007-03-16 [REG HK WD] APPLICATIONS WITHDRAWN, DEEMED TO BE WITHDRAWN, OR REFUSED AFTER PUBLICATION IN HONG KONG

- Document: HK 1027801

2002-04-17 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20011009

2001-07-11 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20010528

2000-05-31 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000118

2000-05-31 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

2000-05-31 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Free text: AL PAYMENT 19990118;LT PAYMENT 19990118;LV PAYMENT 19990118;MK PAYMENT 19990118;RO PAYMENT 19990118;SI PAYMENT 19990118