Global Patent Index - EP 1003713 A1

EP 1003713 A1 2000-05-31 - ANTHRANILIC ACID ANALOGS

Title (en)

ANTHRANILIC ACID ANALOGS

Title (de)

ANTHRANILSÄUREANALOGA

Title (fr)

ANALOGUES D'ACIDE ANTHRANILIQUE

Publication

EP 1003713 A1 (EN)

Application

EP 98938221 A

Priority

  • US 9815981 W
  • US 90593097 A

Abstract (en)

[origin: WO9907670A1] Compounds of formula (I) wherein: R1, R2 and R3 are, independently, hydrogen, nitro, cyano, C1-10 haloalkoxy, amino, C1-10 alkylamino, sulfo, sulfamoyl, C1-10 alkylsulfonamido, C2-10 alkylcarboxamido C2-10 alkanoyl, C1-10 alkylsulfonyl, C1-10 haloalkylsulfonyl, C1-10 carboxyl, C1-10 haloalkyl and C6-12 aryl; with the provisos: (1) that R1, R2 and R3 may not all simultaneously be hydrogen, and (2) when R1 and R2 are hydrogen, R3 may not be meta-CF3; R4, R5 and R6 are, independently , hydrogen, halogen, nitro, cyano, C1-10 carboalkoxy, C1-10 haloalkoxy, amino C1-10 alkylamino, sulfo, sulfamoyl, C1-10 alkylsulfonamido, C2-10 alkylcarboxamido C2-10 alkanoyl, C1-10 alkylsulfonyl, C1-10 haloalkylsulfonyl, C1-10 carboxyl, C1-10 haloalkyl, C1-10 alkyl and C6-12 aryl; R7 is hydrogen , metal cation, acetylamido, alkoxyacetoyl or a related moiety which delivers the carboxylate in vivo; and X, Y and Z may form a C3-13 carbocyclic ring, oxazole, isoxazole, thiazole, isothiazole, furan, thiophene, 2H-pyrrole, pyrrole, 2-pyrroline, 3-pyrroline, imidazole, pyrazole, 1,2,3-oxadiazole or 1,2,3-triazole bound to the carbon skeleton; or pharmaceutically acceptable salts thereof useful in the treatment of disorders associated with smooth muscle contraction via potassium channel and chloride channel modulation.

IPC 1-7 (main, further and additional classification)

C07C 233/63; C07D 263/34; C07D 261/18; A61K 31/16; A61K 31/42

IPC 8 full level (invention and additional information)

A61K 31/16 (2006.01); A61K 31/42 (2006.01); A61K 31/421 (2006.01); A61P 1/00 (2006.01); A61P 9/04 (2006.01); A61P 9/10 (2006.01); A61P 11/06 (2006.01); A61P 13/00 (2006.01); C07C 233/63 (2006.01); C07D 261/18 (2006.01); C07D 263/34 (2006.01)

CPC (invention and additional information)

C07D 263/34 (2013.01); C07C 233/63 (2013.01); C07D 261/18 (2013.01); C07C 2601/10 (2017.05)

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

EPO simple patent family

WO 9907670 A1 19990218; AU 734786 B2 20010621; AU 8679598 A 19990301; BR 9811828 A 20000815; CA 2297409 A1 19990218; CN 1265643 A 20000906; EP 1003713 A1 20000531; JP 2001513527 A 20010904

INPADOC legal status


2007-03-16 [REG HK WD] APPLICATIONS WITHDRAWN, DEEMED TO BE WITHDRAWN, OR REFUSED AFTER PUBLICATION IN HONG KONG

- Document: HK 1027800

2003-03-12 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20020903

2002-06-05 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20020422

2000-05-31 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000118

2000-05-31 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

2000-05-31 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Free text: AL PAYMENT 20000118;LT PAYMENT 20000118;LV PAYMENT 20000118;MK PAYMENT 20000118;RO PAYMENT 20000118;SI PAYMENT 20000118