EP 1003715 A1 20000531 - POLYAMINE TRANSPORT INHIBITORS
Title (en)
POLYAMINE TRANSPORT INHIBITORS
Title (de)
POLYAMIN TRANSPORT INHIBITOREN
Title (fr)
INHIBITEURS DU TRANSPORT DES POLYAMINES
Publication
Application
Priority
US 9807806 W 19980421
Abstract (en)
[origin: WO9954283A1] The present invention describes the design, synthesis and therapeutic use of a variety of novel inhibitors of polyamine transport. The main feature of this class of transport inhibitors is to incorporate a linker or side chain that prevents the uptake of polyamines and helps to conjugate polyamine analogs to form dimers with high inhibitory potency against polyamine uptake. These new compounds incorporate features that are designed to maximize their chemical and metabolic stability and their ability to bind to the polyamine transporter, and to minimize their toxicity by preventing their absorption by the cells. The purpose of such inhibitors is to prevent the uptake or salvaging of circulating polyamines by rapidly proliferating cells such as tumor cells, in order to potentiate the effect of therapeutic inhibitors of polyamine biosynthesis such as alpha-difluoromethylornithene.
IPC 1-7
C07C 237/10; C07C 211/14; C07C 323/41; A61K 31/16; A61K 31/13
IPC 8 full level
C07C 211/14 (2006.01); C07C 211/27 (2006.01); C07C 237/10 (2006.01); C07C 323/41 (2006.01)
CPC (source: EP)
C07C 211/14 (2013.01); C07C 211/27 (2013.01); C07C 237/10 (2013.01); C07C 323/41 (2013.01)
Citation (search report)
See references of WO 9954283A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9954283 A1 19991028; AU 7131698 A 19991108; CA 2304557 A1 19991028; CA 2304557 C 20081230; EP 1003715 A1 20000531
DOCDB simple family (application)
US 9807806 W 19980421; AU 7131698 A 19980421; CA 2304557 A 19980421; EP 98918385 A 19980421