Global patent index - EP 1003715 A1

EP 1003715 A1 2000-05-31 - POLYAMINE TRANSPORT INHIBITORS

Title (en)

POLYAMINE TRANSPORT INHIBITORS

Title (de)

POLYAMIN TRANSPORT INHIBITOREN

Title (fr)

INHIBITEURS DU TRANSPORT DES POLYAMINES

Publication

EP 1003715 A1 (EN)

Application

EP 98918385 A

Priority

US 9807806 W

Abstract (en)

[origin: WO9954283A1] The present invention describes the design, synthesis and therapeutic use of a variety of novel inhibitors of polyamine transport. The main feature of this class of transport inhibitors is to incorporate a linker or side chain that prevents the uptake of polyamines and helps to conjugate polyamine analogs to form dimers with high inhibitory potency against polyamine uptake. These new compounds incorporate features that are designed to maximize their chemical and metabolic stability and their ability to bind to the polyamine transporter, and to minimize their toxicity by preventing their absorption by the cells. The purpose of such inhibitors is to prevent the uptake or salvaging of circulating polyamines by rapidly proliferating cells such as tumor cells, in order to potentiate the effect of therapeutic inhibitors of polyamine biosynthesis such as alpha-difluoromethylornithene.

IPC 1-7 (main, further and additional classification)

C07C 237/10; A61K 31/13; A61K 31/16; C07C 211/14; C07C 323/41

IPC 8 full level (invention and additional information)

C07C 211/14 (2006.01); C07C 211/27 (2006.01); C07C 237/10 (2006.01); C07C 323/41 (2006.01)

CPC (invention and additional information)

C07C 211/14 (2013.01); C07C 211/27 (2013.01); C07C 237/10 (2013.01); C07C 323/41 (2013.01)

Citation (search report)

See references of WO 9954283A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9954283 A1 19991028; AU 7131698 A 19991108; CA 2304557 A1 19991028; CA 2304557 C 20081230; EP 1003715 A1 20000531

INPADOC legal status

2005-11-02 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20050426

2003-05-21 [RAP1] TRANSFER OF RIGHTS OF AN EP PUBLISHED APPLICATION

- Owner name: UNIVERSITE LAVAL

- Ref Legal Event Code: RAP1

2001-06-13 [17Q] FIRST EXAMINATION REPORT

- Ref Legal Event Code: 17Q

- Effective date: 20010427

2000-05-31 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20000320

2000-05-31 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE