EP 1003734 A2 20000531 - ALPHA 1a ADRENERGIC RECEPTOR ANTAGONIST
Title (en)
ALPHA 1a ADRENERGIC RECEPTOR ANTAGONIST
Title (de)
ALFA 1A ADRENERGISCH REZEPTOR ANTAGONIST
Title (fr)
ANTAGONISTE DE RECEPTEUR ADRENERGIQUE ALPHA 1a
Publication
Application
Priority
- GB 9719706 A 19970916
- GB 9719708 A 19970916
- US 9816011 W 19980731
- US 5481597 P 19970805
- US 5490297 P 19970805
- US 12230198 A 19980724
Abstract (en)
[origin: WO9907695A2] This invention relates to crystalline pharmaceutically acceptable salts of an alpha 1a adrenergic receptor antagonist, Compound A, which are useful in the treatment of benign prostatic hyperplasia. Pharmaceutical compositions employing the crystalline salts, and processes for making and using the crystalline salts and pharmaceutical compositions of Compound A are also disclosed. This invention further relates to a process for obtaining enantiomerically pure intermediate useful for the synthesis of end product alpha 1a adrenergic receptor antagonists. The end product compounds are useful for the treatment of benign prostatic hyperplasia and for relaxing lower urinary tract tissue. The invention also relates to a process for preparing a class of dihydropyrimidinone compounds of which Compound A is a member, wherein the process involves deprotonating a dihydropyrimidinone compound and then coupling the deprotonated derivative with a primary amine.
IPC 1-7
IPC 8 full level
A61K 31/513 (2006.01); A61P 13/08 (2006.01); C07D 239/22 (2006.01); C07D 401/04 (2006.01); C07D 401/14 (2006.01)
CPC (source: EP)
A61P 13/08 (2017.12); C07D 239/22 (2013.01); C07D 401/04 (2013.01); C07D 401/14 (2013.01)
Citation (search report)
See references of WO 9907695A2
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
WO 9907695 A2 19990218; WO 9907695 A3 19990617; AU 8680598 A 19990301; CA 2297889 A1 19990218; EP 1003734 A2 20000531; JP 2001512724 A 20010828
DOCDB simple family (application)
US 9816011 W 19980731; AU 8680598 A 19980731; CA 2297889 A 19980731; EP 98938234 A 19980731; JP 2000506199 A 19980731