Global Patent Index - EP 1003743 A1

EP 1003743 A1 2000-05-31 - 3,3-DISUBSTITUTED PIPERIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY

Title (en)

3,3-DISUBSTITUTED PIPERIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY

Title (de)

3,3-DISBSTITUIERTE PIPERIDINE WIE MODULATOREN VON CHEMOKINE-REZEPTOR AKTIVITÄT

Title (fr)

PIPERIDINES 3,3-DISUBSTITUEES UTILISEES COMME MODULATEURS DE L'ACTIVITE DE RECEPTEURS DE CHEMOKINES

Publication

EP 1003743 A1 (EN)

Application

EP 98905975 A

Priority

  • GB 9707490 A
  • US 9801101 W
  • US 3585497 P

Abstract (en)

[origin: WO9831364A1] The present invention is directed to 3,3-disubstituted piperidines of formula (I), (wherein X, Y, Z, Ar, R, m and n are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-1, CCR-2, CCR-2A, CCR-2B, CCR-3, CCR-4, CCR-5, CXCR-3, and/or CXCR-4.

IPC 1-7 (main, further and additional classification)

C07D 471/00; A61K 31/00

IPC 8 full level (invention and additional information)

C07D 221/20 (2006.01); A61K 31/438 (2006.01); A61K 31/445 (2006.01); A61K 31/4535 (2006.01); A61K 31/454 (2006.01); A61K 31/4545 (2006.01); A61P 11/06 (2006.01); A61P 31/18 (2006.01); A61P 37/00 (2006.01); A61P 37/08 (2006.01); A61P 43/00 (2006.01); C07D 211/16 (2006.01); C07D 211/68 (2006.01); C07D 211/76 (2006.01); C07D 401/06 (2006.01); C07D 401/14 (2006.01); C07D 471/10 (2006.01)

CPC (invention and additional information)

C07D 401/06 (2013.01); A61K 31/438 (2013.01); A61K 31/4535 (2013.01); A61K 31/454 (2013.01); A61K 31/4545 (2013.01); C07D 211/16 (2013.01); C07D 211/76 (2013.01); C07D 401/14 (2013.01); C07D 471/10 (2013.01)

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

EPO simple patent family

WO 9831364 A1 19980723; AU 6133098 A 19980807; CA 2278309 A1 19980723; EP 1003743 A1 20000531; EP 1003743 A4 20010411; JP 2001508798 A 20010703

INPADOC legal status


2004-02-11 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20030801

2001-04-11 [A4] SUPPLEMENTARY SEARCH REPORT

- Ref Legal Event Code: A4

- Effective date: 20010228

2001-04-11 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

2001-04-11 [RIC1] CLASSIFICATION (CORRECTION)

- Ref Legal Event Code: RIC1

- Free Format Text: 7C 07D 211/06 A, 7C 07D 211/22 B, 7C 07D 221/20 B, 7C 07D 401/06 B, 7C 07D 401/14 B, 7A 61K 31/44 B, 7A 61K 31/445 B

2000-05-31 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 19990823

2000-05-31 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE