EP 1003743 A4 20010411 - 3,3-DISUBSTITUTED PIPERIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY

Title (en)

3,3-DISUBSTITUTED PIPERIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY

Title (de)

3,3-DISBSTITUIERTE PIPERIDINE WIE MODULATOREN VON CHEMOKINE-REZEPTOR AKTIVITÄT

Title (fr)

PIPERIDINES 3,3-DISUBSTITUEES UTILISEES COMME MODULATEURS DE L'ACTIVITE DE RECEPTEURS DE CHEMOKINES

Publication

EP 1003743 A4 20010411 (EN)

Application

EP 98905975 A 19980120

Priority

GB 9707490 A 19970414
US 9801101 W 19980120
US 3585497 P 19970121

Abstract (en)

[origin: WO9831364A1] The present invention is directed to 3,3-disubstituted piperidines of formula (I), (wherein X, Y, Z, Ar, R, m and n are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-1, CCR-2, CCR-2A, CCR-2B, CCR-3, CCR-4, CCR-5, CXCR-3, and/or CXCR-4.

IPC 1-7

C07D 211/06; C07D 211/22; C07D 221/20; C07D 401/06; C07D 401/14; A61K 31/44; A61K 31/445

IPC 8 full level

C07D 221/20 (2006.01); A61K 31/438 (2006.01); A61K 31/445 (2006.01); A61K 31/4535 (2006.01); A61K 31/454 (2006.01); A61K 31/4545 (2006.01); A61P 11/06 (2006.01); A61P 31/18 (2006.01); A61P 37/00 (2006.01); A61P 37/08 (2006.01); A61P 43/00 (2006.01); C07D 211/16 (2006.01); C07D 211/68 (2006.01); C07D 211/76 (2006.01); C07D 401/06 (2006.01); C07D 401/14 (2006.01); C07D 471/10 (2006.01)

CPC (source: EP)

A61K 31/438 (2013.01); A61K 31/4535 (2013.01); A61K 31/454 (2013.01); A61K 31/4545 (2013.01); A61P 11/06 (2017.12); A61P 31/18 (2017.12); A61P 37/00 (2017.12); A61P 37/08 (2017.12); A61P 43/00 (2017.12); C07D 211/16 (2013.01); C07D 211/76 (2013.01); C07D 401/06 (2013.01); C07D 401/14 (2013.01); C07D 471/10 (2013.01)

Citation (search report)

[E] WO 9811090 A2 19980319 - WARNER LAMBERT CO [US], et al
See references of WO 9831364A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

DOCDB simple family (publication)

WO 9831364 A1 19980723; AU 6133098 A 19980807; CA 2278309 A1 19980723; EP 1003743 A1 20000531; EP 1003743 A4 20010411; JP 2001508798 A 20010703

DOCDB simple family (application)

US 9801101 W 19980120; AU 6133098 A 19980120; CA 2278309 A 19980120; EP 98905975 A 19980120; JP 53466298 A 19980120