EP 1003778 A1 20000531 - ISOLATED OSTEOCALCIN FRAGMENTS
Title (en)
ISOLATED OSTEOCALCIN FRAGMENTS
Title (de)
ISOLIERTE OSTEOCALCIN FRAGMENTEN
Title (fr)
FRAGMENTS ISOLES D'OSTEOCALCINE
Publication
Application
Priority
- FI 9800550 W 19980624
- FI 973371 A 19970815
Abstract (en)
[origin: WO9909058A1] The invention relates to an isolated osteocalcin fragment derived from human urine, said fragment being characterized in that at least one of the glutamic acids in the position 17, 21 and 24 of the amino acid sequence (I) is gamma-carboxylated. The invention concerns further a monoclonal antibody or recombinant antibody fragment capable to bind said fragment, a cell line producing said monoclonal antibody, and an immunoassay for quantitative determination of said fragment. Furthermore, the invention concerns a method for the measurement of the rate of bone turnover (formation and/or resorption) and/or for the investigation of metabolic bone disorders.
IPC 1-7
IPC 8 full level
C07K 14/47 (2006.01); C07K 14/78 (2006.01); C07K 16/18 (2006.01); C12N 5/10 (2006.01); C12N 15/02 (2006.01); C12P 21/08 (2006.01); G01N 33/53 (2006.01); G01N 33/68 (2006.01)
CPC (source: EP)
C07K 14/78 (2013.01); C07K 16/18 (2013.01); G01N 33/6887 (2013.01); G01N 33/6893 (2013.01)
Citation (search report)
See references of WO 9909058A1
Designated contracting state (EPC)
DE ES FR GB IT
DOCDB simple family (publication)
WO 9909058 A1 19990225; EP 1003778 A1 20000531; FI 973371 A0 19970815; JP 2001514875 A 20010918
DOCDB simple family (application)
FI 9800550 W 19980624; EP 98929457 A 19980624; FI 973371 A 19970815; JP 2000509736 A 19980624