Global patent index - EP 1003778 A1

EP 1003778 A1 2000-05-31 - ISOLATED OSTEOCALCIN FRAGMENTS

Title (en)

ISOLATED OSTEOCALCIN FRAGMENTS

Title (de)

ISOLIERTE OSTEOCALCIN FRAGMENTEN

Title (fr)

FRAGMENTS ISOLES D'OSTEOCALCINE

Publication

EP 1003778 A1 (EN)

Application

EP 98929457 A

Priority

  • FI 9800550 W
  • FI 973371 A

Abstract (en)

[origin: WO9909058A1] The invention relates to an isolated osteocalcin fragment derived from human urine, said fragment being characterized in that at least one of the glutamic acids in the position 17, 21 and 24 of the amino acid sequence (I) is gamma-carboxylated. The invention concerns further a monoclonal antibody or recombinant antibody fragment capable to bind said fragment, a cell line producing said monoclonal antibody, and an immunoassay for quantitative determination of said fragment. Furthermore, the invention concerns a method for the measurement of the rate of bone turnover (formation and/or resorption) and/or for the investigation of metabolic bone disorders.

IPC 1-7 (main, further and additional classification)

C07K 14/47; C07K 16/18; G01N 33/68

IPC 8 full level (invention and additional information)

G01N 33/53 (2006.01); C07K 14/47 (2006.01); C07K 14/78 (2006.01); C07K 16/18 (2006.01); C12N 5/10 (2006.01); C12N 15/02 (2006.01); C12P 21/08 (2006.01); G01N 33/68 (2006.01)

CPC (invention and additional information)

C07K 14/78 (2013.01); C07K 16/18 (2013.01); G01N 33/6887 (2013.01); G01N 33/6893 (2013.01)

Citation (search report)

See references of WO 9909058A1

Designated contracting state (EPC)

DE ES FR GB IT

EPO simple patent family

WO 9909058 A1 19990225; EP 1003778 A1 20000531; FI 973371 A0 19970815; JP 2001514875 A 20010918

INPADOC legal status

2009-02-11 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20080826

2000-05-31 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 19991231

2000-05-31 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): DE ES FR GB IT