Global Patent Index - EP 1003848 A2

EP 1003848 A2 2000-05-31 - METHODS FOR ACTIVATING INACTIVE GENES AND METHODS FOR ALTERING THE RATE OF DEVELOPMENT OF CELLS, TISSUES AND ORGANISMS

Title (en)

METHODS FOR ACTIVATING INACTIVE GENES AND METHODS FOR ALTERING THE RATE OF DEVELOPMENT OF CELLS, TISSUES AND ORGANISMS

Title (de)

VERFAHREN ZUR AKTIVIERUNG VON INAKTIVE GENE UND VERFAHREN ZUR ÄNDERUNG DER ENTWICKLUNGSVERHÄLTNISSE VON ZELLEN, GEWEBEN UND ORGANISMEN

Title (fr)

PROCEDES D'ACTIVATION DE GENES INACTIFS ET PROCEDES DE MODIFICATION DE LA VITESSE DE DEVELOPPEMENT DE CELLULES, DE TISSUS, ET D'ORGANISMES

Publication

EP 1003848 A2 (EN)

Application

EP 98923455 A

Priority

  • US 9810006 W
  • US 4803397 P

Abstract (en)

[origin: WO9854310A2] The present invention is based on the unexpected observation that DNA methylation, particularly at cytosine residues, that regulates gene activation states and the rate of development and differentiation of cells and organisms, can be altered by providing methioninase to a cell, tissue or organism. In addition, other methylation reactions within a cell can be altered by providing methioninase to a cell, tissue or organism. Based on these observations, the present invention provides methods of activating inactive genes, methods for decreasing the rate of development of cell, tissues or an organism, methods of treating obesity and methods of treating Parkinson's disease and other neurological disorders, by either providing a methioninase containing composition to a cell, tissue or organism or by introducing a methioninase encoding DNA molecule into the cell, tissue or organism. The present invention further provides organisms and cells that have been altered such that their rate of maturation is decreased and/or the degree of methylation of cellular constituents (DNA, RNA, lipids, proteins small cellular molecules, etc.) is decreased.

IPC 1-7 (main, further and additional classification)

C12N 15/00

IPC 8 full level (invention and additional information)

A01K 67/027 (2006.01); A61K 48/00 (2006.01); C12N 15/67 (2006.01)

CPC (invention and additional information)

C12N 15/67 (2013.01); A01K 67/027 (2013.01); A61K 48/00 (2013.01)

Citation (search report)

See references of WO 9854310A3

Designated contracting state (EPC)

BE CH DE FR GB LI

EPO simple patent family

WO 9854310 A2 19981203; WO 9854310 A3 19990304; EP 1003848 A2 20000531

INPADOC legal status


2005-09-07 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20050308

2002-11-20 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20021004

2000-05-31 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 19991129

2000-05-31 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A2

- Designated State(s): BE CH DE FR GB LI