Title (en)

TRANSFORMED YEAST STRAINS AND THEIR USE FOR THE PRODUCTION OF MONOTERMINAL AND DITERMINAL ALIPHATIC CARBOXYLATES

Title (de)

TRANSFORMIERTE HEFESTÄMME UND IHRE VERWENDUNG ZUR HERSTELLUNG VON MONO- UND DI-TERMINALEN ALIPHATISCHEN CARBOXYLATEN

Title (fr)

SOUCHES DE LEVURE TRANSFORMEES ET LEUR UTILISATION DANS LA PRODUCTION DE CARBOXYLATES ALIPHATIQUES A TERMINAISON UNIQUE ET DOUBLE

Publication

EP 1003881 A2 20000531 (EN)

Application

EP 98935806 A 19980720

Priority

• US 9814935 W 19980720
• US 5321597 P 19970721

Abstract (en)

[origin: WO9904014A2] The present invention comprises a bioprocess for converting aliphatic compounds, of the form CH3(CH2)nCH3 where n = 4 to 20, to monoterminal and diterminal carboxylates using genetically-engineered organisms. This invention relates to a process for expressing alkane hydroxylating activity in genetically-engineered yeasts Pichia pastoris and Candida maltosa. In addition, the present invention describes a process to produce genetically transformed Candida maltosa strains that have enhanced cytochrome P450 activity and/or gene disruptions in the beta -oxidation pathway.

IPC 1-7

C12N 15/53; C12P 7/44; C12P 7/40

IPC 8 full level

C12N 15/09 (2006.01); C12N 1/15 (2006.01); C12N 9/02 (2006.01); C12N 15/53 (2006.01); C12P 7/40 (2006.01); C12P 7/44 (2006.01); C12R 1/84 (2006.01)

CPC (source: EP)

C12N 1/165 (2021.05); C12N 9/0042 (2013.01); C12N 9/0077 (2013.01); C12P 7/40 (2013.01); C12P 7/44 (2013.01); C12R 2001/72 (2021.05); C12R 2001/84 (2021.05)

Citation (search report)

See references of WO 9904014A2

Designated contracting state (EPC)

DE DK ES FR GB IE IT NL SE

DOCDB simple family (publication)

WO 9904014 A2 19990128; WO 9904014 A3 19990520; AU 8498298 A 19990210; CA 2293737 A1 19990128; EP 1003881 A2 20000531; IL 133931 A0 20010430; JP 2001510048 A 20010731

DOCDB simple family (application)

US 9814935 W 19980720; AU 8498298 A 19980720; CA 2293737 A 19980720; EP 98935806 A 19980720; IL 13393198 A 19980720; JP 2000503220 A 19980720