EP 1005360 A1 20000607 - ANTIOXIDANT PROTEIN 2, GENE AND METHODS OF USE THEREFOR
Title (en)
ANTIOXIDANT PROTEIN 2, GENE AND METHODS OF USE THEREFOR
Title (de)
ANTIOXIDANZ PROTEIN 2,GEN SOWIE VERFAHREN ZU DESSEN ANWENDUNG
Title (fr)
PROTEINE ANTI-OXYDANTE 2, GENE ET PROCEDES D'UTILISATION CORRESPONDANTS
Publication
Application
Priority
- US 9806666 W 19980401
- US 4089797 P 19970402
Abstract (en)
[origin: WO9843666A1] The present invention involves the identification of a novel gene and protein, now designated as antioxidant protein 2 (Aop2 and AOP2, respectively). Studies indicate that the Ltw4 and Aop2 are a single gene. In addition, Aop2 also appears to be the gene responsible for the Athl trait in mice - a predisposition to atherosclerotic disease. The human homolog for this gene also has been identified. This discovery makes possible a variety of uses for AOP2 and the corresponding gene, for example, development of reagents (antibodies, expression vectors, cell lines, congenic and transgenic mice) that may be used in the diagnosis and treatment of atherosclerosis and related disease states.
IPC 1-7
A61K 38/43; A61K 39/395; A61K 48/00; C12N 15/11; C12N 9/00; C12N 15/63; C12Q 1/68; C12P 19/34; G01N 33/53
IPC 8 full level
A61K 35/76 (2006.01); A61K 38/00 (2006.01); A61K 45/00 (2006.01); A61K 48/00 (2006.01); A61P 9/10 (2006.01); A61P 43/00 (2006.01); C07K 14/47 (2006.01); C07K 16/18 (2006.01); C12N 1/21 (2006.01); C12N 15/09 (2006.01); C12P 21/08 (2006.01); C12Q 1/68 (2006.01); G01N 33/15 (2006.01); G01N 33/50 (2006.01)
CPC (source: EP)
A61P 9/10 (2017.12); A61P 43/00 (2017.12); C07K 14/47 (2013.01); A61K 38/00 (2013.01); A61K 48/00 (2013.01)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9843666 A1 19981008; CA 2285631 A1 19981008; EP 1005360 A1 20000607; EP 1005360 A4 20010207; JP 2001522229 A 20011113
DOCDB simple family (application)
US 9806666 W 19980401; CA 2285631 A 19980401; EP 98919730 A 19980401; JP 53515698 A 19980401