EP 1005375 A1 20000607 - PHOTODYNAMIC THERAPY GENERATED OXIDATIVE STRESS FOR TEMPORAL AND SELECTIVE EXPRESSION OF HETEROLOGOUS GENES
Title (en)
PHOTODYNAMIC THERAPY GENERATED OXIDATIVE STRESS FOR TEMPORAL AND SELECTIVE EXPRESSION OF HETEROLOGOUS GENES
Title (de)
DURCH PHOTODYNAMISCHE THERAPIE ERZEUGTER OXIDATIVER STRESS ZUR ZEITLICH BEGRENZTEN UND SELEKTIVEN EXPRESSION HETEROLOGER GENE
Title (fr)
STRESS OXYDATIF GENERE PAR TRAITEMENT PHOTODYNAMIQUE POUR L'EXPRESSION TEMPORAIRE ET SELECTIVE DE GENES HETEROLOGUES
Publication
Application
Priority
- US 9804551 W 19980309
- US 81540297 A 19970310
Abstract (en)
[origin: WO9840105A1] The present invention describes a method for the selection and temporal expression of heterologous genes. The invention consists of methods to obtain selective and temporal expression of heterologous genes in target tissues. Promoters inducible by photodynamic therapy or heat are used to express genes of interest under conditions of heating or Photodynamic Therapy-(PDT-) induced oxidative stress. Selective and temporal expression of heterologous genes (such as cytokines, toxins, tumor suppressor genes, antisense molecules and anti-angiogenic factors) are of significant therapeutic benefit in the treatment of tumors, vascular proliferation and tissue hypertrophy. Gene therapy targeted by laser induced heating, other heating sources (such as microwave, ultrasound or radiofrequency induced currents), or PDT enhances treatment effectiveness by inducing expression of therapeutic genes in a controlled and localized manner.
IPC 1-7
IPC 8 full level
A61K 31/195 (2006.01); A61K 31/409 (2006.01); A61K 31/4188 (2006.01); A61K 31/7088 (2006.01); A61K 41/00 (2006.01); A61K 48/00 (2006.01); A61P 43/00 (2006.01); C12N 13/00 (2006.01); C12N 15/67 (2006.01); C12N 15/85 (2006.01)
CPC (source: EP KR)
A61K 48/00 (2013.01 - EP KR); A61P 43/00 (2017.12 - EP); C12N 13/00 (2013.01 - EP); C12N 15/67 (2013.01 - EP); C12N 15/85 (2013.01 - EP); C12N 2830/002 (2013.01 - EP); C12N 2830/85 (2013.01 - EP)
Citation (search report)
See references of WO 9840105A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9840105 A1 19980917; AU 6453998 A 19980929; AU 731502 B2 20010329; CA 2283108 A1 19980917; CN 1252006 A 20000503; EP 1005375 A1 20000607; IL 131776 A0 20010319; JP 2001514658 A 20010911; KR 20000076115 A 20001226; NZ 337693 A 20010727; ZA 981948 B 19990909
DOCDB simple family (application)
US 9804551 W 19980309; AU 6453998 A 19980309; CA 2283108 A 19980309; CN 98804010 A 19980309; EP 98910249 A 19980309; IL 13177698 A 19980309; JP 53966198 A 19980309; KR 19997008203 A 19990909; NZ 33769398 A 19980309; ZA 981948 A 19980309