Global Patent Index - EP 1005375 A1

EP 1005375 A1 2000-06-07 - PHOTODYNAMIC THERAPY GENERATED OXIDATIVE STRESS FOR TEMPORAL AND SELECTIVE EXPRESSION OF HETEROLOGOUS GENES

Title (en)

PHOTODYNAMIC THERAPY GENERATED OXIDATIVE STRESS FOR TEMPORAL AND SELECTIVE EXPRESSION OF HETEROLOGOUS GENES

Title (de)

DURCH PHOTODYNAMISCHE THERAPIE ERZEUGTER OXIDATIVER STRESS ZUR ZEITLICH BEGRENZTEN UND SELEKTIVEN EXPRESSION HETEROLOGER GENE

Title (fr)

STRESS OXYDATIF GENERE PAR TRAITEMENT PHOTODYNAMIQUE POUR L'EXPRESSION TEMPORAIRE ET SELECTIVE DE GENES HETEROLOGUES

Publication

EP 1005375 A1 (EN)

Application

EP 98910249 A

Priority

  • US 9804551 W
  • US 81540297 A

Abstract (en)

[origin: WO9840105A1] The present invention describes a method for the selection and temporal expression of heterologous genes. The invention consists of methods to obtain selective and temporal expression of heterologous genes in target tissues. Promoters inducible by photodynamic therapy or heat are used to express genes of interest under conditions of heating or Photodynamic Therapy-(PDT-) induced oxidative stress. Selective and temporal expression of heterologous genes (such as cytokines, toxins, tumor suppressor genes, antisense molecules and anti-angiogenic factors) are of significant therapeutic benefit in the treatment of tumors, vascular proliferation and tissue hypertrophy. Gene therapy targeted by laser induced heating, other heating sources (such as microwave, ultrasound or radiofrequency induced currents), or PDT enhances treatment effectiveness by inducing expression of therapeutic genes in a controlled and localized manner.

IPC 1-7 (main, further and additional classification)

A61K 48/00; C12N 13/00; C12N 15/00

IPC 8 full level (invention and additional information)

A61K 31/195 (2006.01); A61K 31/409 (2006.01); A61K 31/4188 (2006.01); A61K 31/7088 (2006.01); A61K 41/00 (2006.01); A61K 48/00 (2006.01); A61P 43/00 (2006.01); C12N 13/00 (2006.01); C12N 15/67 (2006.01); C12N 15/85 (2006.01)

CPC (invention and additional information)

A61K 48/00 (2013.01); C12N 13/00 (2013.01); C12N 15/67 (2013.01); C12N 15/85 (2013.01); C12N 2830/002 (2013.01); C12N 2830/85 (2013.01)

Citation (search report)

See references of WO 9840105A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9840105 A1 19980917; AU 6453998 A 19980929; AU 731502 B2 20010329; CA 2283108 A1 19980917; CN 1252006 A 20000503; EP 1005375 A1 20000607; IL 131776 D0 20010319; JP 2001514658 A 20010911; KR 20000076115 A 20001226; NZ 337693 A 20010727; ZA 9801948 B 19990909

INPADOC legal status


2004-05-12 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20031001

2000-06-07 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 19991007

2000-06-07 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE