Global Patent Index - EP 1005466 A1

EP 1005466 A1 2000-06-07 - TETRAETHER LIPID DERIVATIVES AND LIPOSOMES AND LIPID AGGLOMERATES CONTAINING TETRAETHERLIPID DERIVATIVES, AND USE THEREOF

Title (en)

TETRAETHER LIPID DERIVATIVES AND LIPOSOMES AND LIPID AGGLOMERATES CONTAINING TETRAETHERLIPID DERIVATIVES, AND USE THEREOF

Title (de)

TETRAETHERLIPIDDERIVATE UND TETRAETHERLIPIDDERIVATE ENTHALTENDE LIPOSOMEN UND LIPIDAGGLOMERATE SOWIE DEREN VERWENDUNG

Title (fr)

DERIVES DE TETRAETHERLIPIDES, LIPOSOMES CONTENANT DES DERIVES DE TETRAETHERLIPIDES ET AGGLOMERATS DE LIPIDIQUES AINSI QUE LEUR UTILISATION

Publication

EP 1005466 A1 (DE)

Application

EP 98946380 A

Priority

  • DE 19736592 A
  • EP 9805264 W

Abstract (en)

[origin: DE19736592A1] Macrocyclic tetraether lipid derivatives (I) and liposomes or liposome aggregates containing (I) are new. Tetraether lipid derivatives of formula (I), consisting of a 72-membered macrocyclic dibiphytanyl-diethyl-tetraether ring derivatized by two substituted carbamoyl groups, and derivatives of (I) modified by the formation of 'pentacycles' in the tetraether structure, are new. S1,S2 = -CONH-X1-N(R1)n-X2-Y; Y = NR2R3 or -N<+>R4R5R6; X1,X2 = 2-20C alkylene or alkenylene; R1-R6 = H or alkyl, alkenyl, aralkyl or aryl (all of up to 12C); or one of R1-R6 = antibody against cell surface molecules or ligand for cell surface receptors; n = 0-10. Independent claims are included for liposomes and lipid aggregates containing at least one compound (I), optionally together with a nucleic acid molecule.

IPC 1-7 (main, further and additional classification)

C07D 323/00; A61K 9/127

IPC 8 full level (invention and additional information)

A61K 9/127 (2006.01); A61K 48/00 (2006.01); C07D 323/00 (2006.01); C12N 15/88 (2006.01)

CPC (invention and additional information)

C07D 323/00 (2013.01); A61K 9/1272 (2013.01); A61K 48/00 (2013.01); C12N 15/88 (2013.01)

Citation (search report)

See references of WO 9910337A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI NL PT SE

EPO simple patent family

DE 19736592 A1 19990225; DE 19736592 C2 20020124; AU 9344398 A 19990316; CA 2269502 A1 19990304; CA 2269502 C 20030729; EP 1005466 A1 20000607; WO 9910337 A1 19990304

INPADOC legal status


2008-08-27 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20080301

2000-07-19 [RAP1] TRANSFER OF RIGHTS OF AN EP PUBLISHED APPLICATION

- Owner name: BERNINA BIOSYSTEMS GMBH

2000-06-07 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 19990326

2000-06-07 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI NL PT SE

2000-06-07 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Free text: LT PAYMENT 19990326;SI PAYMENT 19990326