Global Patent Index - EP 1005655 A2

EP 1005655 A2 2000-06-07 - METHOD OF DRUG SELECTION

Title (en)

METHOD OF DRUG SELECTION

Title (de)

VERFAHREN ZUR AUSWAHL VON DROGEN

Title (fr)

PROCEDE DE SELECTION DE MEDICAMENTS

Publication

EP 1005655 A2 (EN)

Application

EP 98939765 A

Priority

  • GB 9802504 W
  • GB 9717652 A

Abstract (en)

[origin: WO9909416A2] The invention provides a method for selecting a candidate drug compound, said method comprising: i) identifying a starting oligopeptide having a binding affinity for a cell surface or other receptor site; ii) generating a plurality of homologous oligopeptides having single site amino acid modifications relative to said starting oligopeptide; iii) identifying components of said starting oligopeptide responsible for the secondary structure thereof; iv) for modification sites identified in step (ii) selecting a set of amino acids; v) for components identified in step (iii) selecting at least one non-natural amino acid which mimics the secondary structure of the component; vi) generating a first combinatorial library of oligopeptides having at said identified modification sites amino acid residues corresponding to said selected sets of amino acids; vii) identifying members of said first library having a binding affinity value above a predetermined minimum and generating a further combinatorial library of oligopeptides having members not present in said first library, and identifying members of said further library having improved binding affinity values relative to the identified members of said first library and with the proviso that at least one of said first and further libraries contains oligopeptides containing residues of said non-natural amino acid or acids; and (viii) selecting from the identified members of said library or libraries a drug candidate.

IPC 1-7 (main, further and additional classification)

G01N 33/68; C07K 1/04

IPC 8 full level (invention and additional information)

G01N 33/50 (2006.01); A61K 38/00 (2006.01); C07K 1/04 (2006.01); C40B 30/04 (2006.01); G01N 33/15 (2006.01); G01N 33/566 (2006.01); G01N 33/68 (2006.01)

IPC 8 main group level (invention and additional information)

G01N (2006.01)

CPC (invention and additional information)

C40B 30/04 (2013.01); C07K 1/047 (2013.01); G01N 33/6845 (2013.01); G01N 2333/245 (2013.01)

Citation (search report)

See references of WO 9909416A3

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9909416 A2 19990225; WO 9909416 A3 19991021; AU 8816898 A 19990308; AU 8817398 A 19990308; CA 2300903 A1 19990225; EP 1005655 A2 20000607; GB 9717652 D0 19971022; JP 2001516029 A 20010925; NO 20000811 A 20000412; NO 20000811 D0 20000218; WO 9909417 A2 19990225; WO 9909417 A3 19990812; WO 9909417 A9 19990527

INPADOC legal status


2004-09-01 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20040301

2002-05-02 [RAP1] TRANSFER OF RIGHTS OF AN EP PUBLISHED APPLICATION

- Owner name: AMERSHAM HEALTH AS

- Ref Legal Event Code: RAP1

2000-06-07 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20000320

2000-06-07 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2000-06-07 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Ref Legal Event Code: AX

- Free Format Text: AL PAYMENT 20000320;LT PAYMENT 20000320;LV PAYMENT 20000320;MK PAYMENT 20000320;RO PAYMENT 20000320;SI PAYMENT 20000320