EP 1005655 A2 20000607 - METHOD OF DRUG SELECTION
Title (en)
METHOD OF DRUG SELECTION
Title (de)
VERFAHREN ZUR AUSWAHL VON DROGEN
Title (fr)
PROCEDE DE SELECTION DE MEDICAMENTS
Publication
Application
Priority
- GB 9802504 W 19980820
- GB 9717652 A 19970820
Abstract (en)
[origin: WO9909416A2] The invention provides a method for selecting a candidate drug compound, said method comprising: i) identifying a starting oligopeptide having a binding affinity for a cell surface or other receptor site; ii) generating a plurality of homologous oligopeptides having single site amino acid modifications relative to said starting oligopeptide; iii) identifying components of said starting oligopeptide responsible for the secondary structure thereof; iv) for modification sites identified in step (ii) selecting a set of amino acids; v) for components identified in step (iii) selecting at least one non-natural amino acid which mimics the secondary structure of the component; vi) generating a first combinatorial library of oligopeptides having at said identified modification sites amino acid residues corresponding to said selected sets of amino acids; vii) identifying members of said first library having a binding affinity value above a predetermined minimum and generating a further combinatorial library of oligopeptides having members not present in said first library, and identifying members of said further library having improved binding affinity values relative to the identified members of said first library and with the proviso that at least one of said first and further libraries contains oligopeptides containing residues of said non-natural amino acid or acids; and (viii) selecting from the identified members of said library or libraries a drug candidate.
IPC 1-7
IPC 8 full level
A61K 38/00 (2006.01); C07K 1/04 (2006.01); C40B 30/04 (2006.01); G01N 33/15 (2006.01); G01N 33/50 (2006.01); G01N 33/566 (2006.01); G01N 33/68 (2006.01)
IPC 8 main group level
G01N (2006.01)
CPC (source: EP)
C07K 1/047 (2013.01); C40B 30/04 (2013.01); G01N 33/6845 (2013.01); G01N 2333/245 (2013.01)
Citation (search report)
See references of WO 9909416A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9909416 A2 19990225; WO 9909416 A3 19991021; AU 8816898 A 19990308; AU 8817398 A 19990308; CA 2300903 A1 19990225; EP 1005655 A2 20000607; GB 9717652 D0 19971022; JP 2001516029 A 20010925; NO 20000811 D0 20000218; NO 20000811 L 20000412; WO 9909417 A2 19990225; WO 9909417 A3 19990812; WO 9909417 A9 19990527
DOCDB simple family (application)
GB 9802504 W 19980820; AU 8816898 A 19980820; AU 8817398 A 19980820; CA 2300903 A 19980820; EP 98939765 A 19980820; GB 9717652 A 19970820; GB 9802510 W 19980820; JP 2000510029 A 19980820; NO 20000811 A 20000218