EP 1007043 B9 20041222 - METHOD FOR TREATMENT OF CNS-INVOLVED LYSOSOMAL STORAGE DISEASES
Title (en)
METHOD FOR TREATMENT OF CNS-INVOLVED LYSOSOMAL STORAGE DISEASES
Title (de)
VERFAHREN ZUR BEHANDLUNG VON ZNS-BETEILIGTEN LYSOSMALEN SPEICHERKRANKHEITEN
Title (fr)
PROCEDE DE TRAITEMENT DES MALADIES DE SURCHARGE LYSOSOMIALES AFFECTANT LE SYSTEME NERVEUX CENTRAL
Publication
Application
Priority
- US 9800031 W 19980113
- US 78232197 A 19970113
Abstract (en)
[origin: EP1491196A2] A method is disclosed for the in vivo treatment of patients having a Lysosomal storage disease with a significant central nervous system (CNS) involvement. Said method comprises administration to said patient a small but storage-inhibitory effective amount of an N-alkyl derivative of 1,5-dideoxy-1,5-imino-D-galactitol, or an O-acylated pro-drug thereof, in which said alkyl group contains from about 2 to about 8 carbon atoms. The Lysosomal storage diseases having a significant CNS involvement are illustrated by Tay-Sachs disease, Sandhoff disease, GM1 gangliosidosis and Fabray disease. <IMAGE>
IPC 1-7
IPC 8 full level
C07H 15/12 (2006.01); A61K 31/445 (2006.01); A61K 31/70 (2006.01); A61K 31/7028 (2006.01); A61P 3/00 (2006.01); A61P 25/00 (2006.01)
CPC (source: EP US)
A61K 31/445 (2013.01 - EP US); A61K 31/70 (2013.01 - EP US); A61K 31/7004 (2013.01 - EP US); A61K 31/7012 (2013.01 - EP US); A61P 3/00 (2018.01 - EP); A61P 25/00 (2018.01 - EP)
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
WO 9830219 A1 19980716; AT E268598 T1 20040615; AU 5813898 A 19980803; CA 2278507 A1 19980716; CA 2278507 C 20070828; DE 69824421 D1 20040715; DE 69824421 T2 20050303; DK 1007043 T3 20041011; EP 1007043 A1 20000614; EP 1007043 B1 20040609; EP 1007043 B9 20041222; EP 1491196 A2 20041229; EP 1491196 A3 20050316; ES 2223118 T3 20050216; JP 2001508064 A 20010619; PT 1007043 E 20041029; US 5798366 A 19980825
DOCDB simple family (application)
US 9800031 W 19980113; AT 98901673 T 19980113; AU 5813898 A 19980113; CA 2278507 A 19980113; DE 69824421 T 19980113; DK 98901673 T 19980113; EP 04013466 A 19980113; EP 98901673 A 19980113; ES 98901673 T 19980113; JP 53098198 A 19980113; PT 98901673 T 19980113; US 78232197 A 19970113