Global Patent Index - EP 1007051 A4

EP 1007051 A4 20010829 - INTEGRIN RECEPTOR ANTAGONISTS

Title (en)

INTEGRIN RECEPTOR ANTAGONISTS

Title (de)

INTEGRIN REZEPTOR ANTAGONISTEN

Title (fr)

ANTAGONISTES DU RECEPTEUR DE L'INTEGRINE

Publication

EP 1007051 A4 20010829 (EN)

Application

EP 98938357 A 19980804

Priority

  • US 9816246 W 19980804
  • US 5470397 P 19970804
  • US 6352697 P 19971029

Abstract (en)

[origin: WO9906049A1] Compounds of the formula (I) are disclosed which are dual fibrinogen receptor and vitronectin receptor antagonists and are useful in the treatment of atherosclerosis, in the prevention of restenosis and in the prevention of tumor metastasis and tumor growth.

IPC 1-7

A61K 31/55; C07D 223/16; C07D 243/14; C07D 267/14; C07D 281/10; C07D 401/14; C07D 403/12

IPC 8 full level

C07D 223/16 (2006.01); A61K 31/5513 (2006.01); A61K 31/553 (2006.01); A61K 31/554 (2006.01); A61P 9/10 (2006.01); A61P 43/00 (2006.01); C07D 267/14 (2006.01); C07D 281/10 (2006.01); C07D 401/14 (2006.01); C07D 403/14 (2006.01)

CPC (source: EP)

A61P 9/10 (2017.12); A61P 43/00 (2017.12); C07D 401/14 (2013.01)

Citation (search report)

  • [YD] WO 9701540 A1 19970116 - SMITHKLINE BEECHAM CORP [US], et al
  • [Y] WO 9626190 A1 19960829 - SMITHKLINE BEECHAM CORP [US], et al
  • [Y] WO 9600574 A1 19960111 - SMITHKLINE BEECHAM CORP [US], et al
  • [YD] WO 9414776 A2 19940707 - SMITHKLINE BEECHAM CORP [US], et al
  • [Y] WILLIAM E. BONDINELLI ET AL.: "Design of a potent and Orally active Nonpeptide platelet Fibrinogen Receptor (GPIIb/IIIa) Antagonist", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 2, no. 9, 1994, pages 897 - 908, XP000196285
  • [Y] WILLIAM H. MILLER ET AL.: "Structure-Activity Relationships in 3-oxo-1,4-benzodiazepine-2-acetic Acid GPIIb/IIIA antagonists. The 2-benzazepine series", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 6, no. 21, 1996, pages 2481 - 2486, XP004135899
  • [Y] RICHARD M. KEENAN ET AL.: "Discovery of potent nonpeptide Vitronectin Receptor (avb3) Antagonists", JOURNAL OF MEDICINAL CHEMISTRY, vol. 40, no. 15, 18 July 1997 (1997-07-18), pages 2289 - 2292, XP002933333
  • See references of WO 9906049A1

Designated contracting state (EPC)

BE CH DE ES FR GB IT LI NL

DOCDB simple family (publication)

WO 9906049 A1 19990211; AU 8689798 A 19990222; CA 2298544 A1 19990211; EP 1007051 A1 20000614; EP 1007051 A4 20010829; JP 2001511452 A 20010814

DOCDB simple family (application)

US 9816246 W 19980804; AU 8689798 A 19980804; CA 2298544 A 19980804; EP 98938357 A 19980804; JP 2000504863 A 19980804