Global Patent Index - EP 1007076 A1

EP 1007076 A1 2000-06-14 - METHOD OF ANTAGONIZING THE HUMAN SRC SH2 DOMAIN

Title (en)

METHOD OF ANTAGONIZING THE HUMAN SRC SH2 DOMAIN

Title (de)

VERFAHREN ZUR ANTAGONISIERUNG DER HUMANEN SRC SH2-DOMÄNE

Title (fr)

PROCEDE PERMETTANT D'ANTAGONISER LE DOMAINE HUMAIN SRC SH2

Publication

EP 1007076 A1 (EN)

Application

EP 98910294 A

Priority

  • US 9804699 W
  • US 4065897 P

Abstract (en)

[origin: WO9840093A1] Invented is a method of treating a bone resorption disease in a subject which comprises administering to the subject a therapeutically effective amount of a compound which forms a covalent bond or link to cys 185 of the src SH2 domain. Preferred compounds for use herein are the presently invented compounds of formula (I): X = OR'', SR'', NR'', R'''; R'' = H, methyl, alkyl; R''' = CONH2, CONHMe, CO NHalkyl, SONH2, SONHMe, SONHalkyl, SO2NH2, SO2NHMe, SO2NHalkyl; n = 0,1,2; R = H, CH2CH(NHCOR'''')CONHR''''', organic moiety; R'''' = glu-glu-ileu-glu-NH2, peptide, peptidomimetic, alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl; R' = H, peptidomimetic; or R,R' = fused ring system substituted with H or peptidomimetic, or a pharmaceutically acceptable salt, hydrate of solvate thereof. Also invented are pharmaceutical composition comprising a suitable pharmaceutical carrier and a compound of Formula (I).

IPC 1-7 (main, further and additional classification)

A61K 38/05; A01N 43/02; A01N 43/08; A01N 43/16; A01N 43/30; C07K 7/06

IPC 8 full level (invention and additional information)

A61K 45/00 (2006.01); A61K 38/00 (2006.01); A61K 38/07 (2006.01); A61P 19/08 (2006.01); A61P 19/10 (2006.01); A61P 43/00 (2006.01); C07K 7/06 (2006.01)

CPC (invention and additional information)

C07K 7/06 (2013.01); A61K 38/07 (2013.01)

Designated contracting state (EPC)

BE CH DE ES FR GB IT LI NL

EPO simple patent family

WO 9840093 A1 19980917; CA 2283472 A1 19980917; EP 1007076 A1 20000614; EP 1007076 A4 20041027; JP 2001514662 A 20010911

INPADOC legal status


2005-06-22 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20041124

2004-10-27 [A4] DESPATCH OF SUPPLEMENTARY SEARCH REPORT

- Effective date: 20040909

2004-10-27 [RIC1] CLASSIFICATION (CORRECTION)

- IPC: 7A 61K 38/05 A

2004-10-27 [RIC1] CLASSIFICATION (CORRECTION)

- IPC: 7A 01N 43/02 B

2004-10-27 [RIC1] CLASSIFICATION (CORRECTION)

- IPC: 7A 01N 43/08 B

2004-10-27 [RIC1] CLASSIFICATION (CORRECTION)

- IPC: 7A 01N 43/16 B

2004-10-27 [RIC1] CLASSIFICATION (CORRECTION)

- IPC: 7A 01N 43/30 B

2004-10-27 [RIC1] CLASSIFICATION (CORRECTION)

- IPC: 7C 07K 7/06 B

2000-06-14 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 19990908

2000-06-14 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): BE CH DE ES FR GB IT LI NL