EP 1007501 A1 20000614 - PROCESS FOR PRODUCING DIPHENYLETHERS AND ESTERS
Title (en)
PROCESS FOR PRODUCING DIPHENYLETHERS AND ESTERS
Title (de)
VERFAHREN ZUM HERSTELLEN VON DIPHENYLÄTHERN UND ESTERN
Title (fr)
PROCEDE DE PRODUCTION DE DIPHENYLETHERS ET D'ESTERS
Publication
Application
Priority
- US 9817873 W 19980828
- US 92097197 A 19970829
Abstract (en)
[origin: WO9910310A1] An improved synthesis of diphenylethers, and in particular, the bacteriostat 2,4,4'-trichloro-2'-hydroxydiphenylether, is described wherein 2'-acetyl-2,4,4'-trichlorodiphenylether is oxidised under Baeyer-Villiger conditions to produce 2'-acetoxy-2,4,4'-trichlorodiphenylether in near quantitative yield. Best oxidative conditions include the use of anhydrous permaleic acid produced in situ. The ester is purified readily by simple recrystallization, as no dibenzofurans and only minor amounts of byproducts are formed in the process. The ester is converted into the desired halogenated phenolic diphenylether, 2,4,4'-trichloro-2'-hydroxydiphenylether, by hydrolysis or transesterification. The final product is purified to a high degree by vacuum distillation and crystallization to meet current purity standards for approved applications.
IPC 1-7
C07C 67/42; C07C 69/017; C07C 69/63; C07C 41/26; C07C 67/03; C07C 45/64; C07C 49/825
IPC 8 full level
C07C 43/295 (2006.01); C07C 45/46 (2006.01); C07C 45/71 (2006.01); C07C 49/84 (2006.01); C07C 67/42 (2006.01)
CPC (source: EP)
C07C 43/295 (2013.01); C07C 45/46 (2013.01); C07C 45/71 (2013.01); C07C 49/84 (2013.01); C07C 67/42 (2013.01)
Citation (search report)
See references of WO 9910310A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9910310 A1 19990304; AU 9124798 A 19990316; EP 1007501 A1 20000614
DOCDB simple family (application)
US 9817873 W 19980828; AU 9124798 A 19980828; EP 98943452 A 19980828