Global Patent Index - EP 1007501 A1

EP 1007501 A1 2000-06-14 - PROCESS FOR PRODUCING DIPHENYLETHERS AND ESTERS

Title (en)

PROCESS FOR PRODUCING DIPHENYLETHERS AND ESTERS

Title (de)

VERFAHREN ZUM HERSTELLEN VON DIPHENYLÄTHERN UND ESTERN

Title (fr)

PROCEDE DE PRODUCTION DE DIPHENYLETHERS ET D'ESTERS

Publication

EP 1007501 A1 (EN)

Application

EP 98943452 A

Priority

  • US 9817873 W
  • US 92097197 A

Abstract (en)

[origin: WO9910310A1] An improved synthesis of diphenylethers, and in particular, the bacteriostat 2,4,4'-trichloro-2'-hydroxydiphenylether, is described wherein 2'-acetyl-2,4,4'-trichlorodiphenylether is oxidised under Baeyer-Villiger conditions to produce 2'-acetoxy-2,4,4'-trichlorodiphenylether in near quantitative yield. Best oxidative conditions include the use of anhydrous permaleic acid produced in situ. The ester is purified readily by simple recrystallization, as no dibenzofurans and only minor amounts of byproducts are formed in the process. The ester is converted into the desired halogenated phenolic diphenylether, 2,4,4'-trichloro-2'-hydroxydiphenylether, by hydrolysis or transesterification. The final product is purified to a high degree by vacuum distillation and crystallization to meet current purity standards for approved applications.

IPC 1-7 (main, further and additional classification)

C07C 67/42; C07C 41/26; C07C 45/64; C07C 49/825; C07C 67/03; C07C 69/017; C07C 69/63

IPC 8 full level (invention and additional information)

C07C 43/295 (2006.01); C07C 45/46 (2006.01); C07C 45/71 (2006.01); C07C 49/84 (2006.01); C07C 67/42 (2006.01)

CPC (invention and additional information)

C07C 45/71 (2013.01); C07C 43/295 (2013.01); C07C 45/46 (2013.01); C07C 49/84 (2013.01); C07C 67/42 (2013.01)

Combination set (CPC)

  1. C07C 45/46 + C07C 49/807
  2. C07C 45/71 + C07C 49/84
  3. C07C 67/42 + C07C 69/017
  4. C07C 67/42 + C07C 69/63

Citation (search report)

See references of WO 9910310A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9910310 A1 19990304; AU 9124798 A 19990316; EP 1007501 A1 20000614

INPADOC legal status


2002-04-10 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20010926

2001-06-27 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20010515

2000-06-14 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000329

2000-06-14 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE