EP 1007515 A1 20000614 - ARYLPYRIDAZINONES AS PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE BIOSYNTHESIS INHIBITORS
Title (en)
ARYLPYRIDAZINONES AS PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE BIOSYNTHESIS INHIBITORS
Title (de)
ARYLPYRIDAZINONE ALS HEMMER DER BIOSYNTHESE DER PROSTAGLANDIN-ENDOPEROXID-H-SYNTHASE
Title (fr)
ARYLPYRIDAZINONES INHIBITRICES DE LA BIOSYNTHESE DE LA PROSTAGLANDINE ENDOPEROXYDE H SYNTHASE
Publication
Application
Priority
- US 9816479 W 19980810
- US 91702397 A 19970822
Abstract (en)
[origin: WO9910331A1] The present invention describes pyridazinone compounds which are cyclooxygenase (COX) inhibitors, and in particular, are selective inhibitors of cyclooxygenase-2 (COX/2), COX-2 is the inducible isoform associated with inflammation, as opposed to the constitutive isoform, cyclooxygenase-1 (COX-1) which is an important "housekeeping" enzyme in many tissues, including the gastrointestinal (GI) tract and the kidneys. The selectivity of these compounds for COX-2 minimizes the unwanted GI and renal side-effects seen with currently marketed non-steroidal anti-inflammatory drugs (NSAIDs).
IPC 1-7
C07D 237/14; C07D 401/06; C07D 403/06; C07D 237/18; C07D 409/06; C07D 413/06; C07D 405/06; A61K 31/50; C07F 11/00
IPC 8 full level
C07D 237/14 (2006.01); C07D 237/18 (2006.01); C07D 401/06 (2006.01); C07D 401/12 (2006.01); C07D 403/06 (2006.01); C07D 403/12 (2006.01); C07D 405/06 (2006.01); C07D 409/06 (2006.01); C07D 409/12 (2006.01); C07D 417/06 (2006.01)
CPC (source: EP)
C07D 237/14 (2013.01); C07D 237/18 (2013.01); C07D 401/06 (2013.01); C07D 401/12 (2013.01); C07D 403/06 (2013.01); C07D 403/12 (2013.01); C07D 405/06 (2013.01); C07D 409/06 (2013.01); C07D 409/12 (2013.01); C07D 417/06 (2013.01)
Citation (search report)
See references of WO 9910331A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE
Designated extension state (EPC)
RO SI
DOCDB simple family (publication)
WO 9910331 A1 19990304; BR 9812127 A 20000718; CA 2299300 A1 19990304; CA 2299300 C 20070417; CO 4970740 A1 20001107; EP 1007515 A1 20000614; SA 98190764 B1 20060806; TW I232216 B 20050511; ZA 987555 B 19990223
DOCDB simple family (application)
US 9816479 W 19980810; BR 9812127 A 19980810; CA 2299300 A 19980810; CO 98047584 A 19980820; EP 98938451 A 19980810; SA 98190764 A 19981116; TW 87113837 A 19980910; ZA 987555 A 19980820