Global Patent Index - EP 1007526 A1

EP 1007526 A1 2000-06-14 - SUBSTITUTED 4-OXO-NAPTHYRIDINE-3-CARBOXAMIDES AS GABA BRAIN RECEPTOR LIGANDS

Title (en)

SUBSTITUTED 4-OXO-NAPTHYRIDINE-3-CARBOXAMIDES AS GABA BRAIN RECEPTOR LIGANDS

Title (de)

SUBSTITUIERTE 4-OXO-NAPHTHYRIDINE-3-CARBONSAEUREAMIDE ALS GABA-REZEPTORLIGANDEN DES GEHIRNS

Title (fr)

4-OXO-NAPHTYRIDINE-3-CARBOXAMIDES SUBSTITUES COMME LIGANDS DE RECEPTEUR DE GABA DU CERVEAU

Publication

EP 1007526 A1 (EN)

Application

EP 98943352 A

Priority

  • US 9817513 W
  • US 91818097 A

Abstract (en)

[origin: WO9910347A1] The present invention encompasses structures of Formula (I) or the pharmaceutically acceptable non-toxic salts thereof wherein: X is hydrogen, halogen, (un)substituted alkyl, (un)substituted alkoxy or amino; and Y is (un)substituted alkyl, aryl, or heteroaryl, which compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAa brain receptors. These compounds are useful in the diagnosis and treatment of anxiety, Down Syndrome, sleep, cognitive and seizure disorders, and overdose with benzodiazepine drugs and for enhancement of alertness.

IPC 1-7 (main, further and additional classification)

C07D 471/04; A61K 31/44

IPC 8 full level (invention and additional information)

A61K 31/4375 (2006.01); A61K 31/496 (2006.01); A61P 21/02 (2006.01); A61P 25/08 (2006.01); A61P 25/20 (2006.01); A61P 25/22 (2006.01); C07D 471/04 (2006.01)

IPC 8 main group level (invention and additional information)

C07D 221/00 (2006.01)

CPC (invention and additional information)

C07D 471/04 (2013.01)

Citation (search report)

See references of WO 9910347A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9910347 A1 19990304; AP 200001742 D0 20000331; AU 753800 B2 20021031; AU 9117398 A 19990316; BG 104192 A 20010531; BR 9811362 A 20000822; CA 2301599 A1 19990304; CA 2301599 C 20030325; CN 1268136 A 20000927; EG 21717 A 20020227; EP 1007526 A1 20000614; HU 0003258 A2 20010328; HU 0003258 A3 20010528; IL 134291 D0 20010430; IS 5382 A 20000222; JP 2001514181 A 20010911; LV 12539 A 20001020; LV 12539 B 20010120; NO 20000822 A 20000413; NO 20000822 D0 20000218; NZ 502548 A 20020628; OA 11293 A 20021119; PE 130999 A1 19991216; PL 338783 A1 20001120; SI 20270 A 20001231; SK 2162000 A3 20010312; TW 574221 B 20040201; YU 10500 A 20021018

INPADOC legal status


2006-07-05 [18W] WITHDRAWN

- Effective date: 20060525

2000-06-14 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000324

2000-06-14 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2000-06-14 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Free text: AL PAYMENT 20000324;LT PAYMENT 20000324;LV PAYMENT 20000324;MK PAYMENT 20000324;RO PAYMENT 20000324;SI PAYMENT 20000324