EP 1007526 A1 20000614 - SUBSTITUTED 4-OXO-NAPTHYRIDINE-3-CARBOXAMIDES AS GABA BRAIN RECEPTOR LIGANDS
Title (en)
SUBSTITUTED 4-OXO-NAPTHYRIDINE-3-CARBOXAMIDES AS GABA BRAIN RECEPTOR LIGANDS
Title (de)
SUBSTITUIERTE 4-OXO-NAPHTHYRIDINE-3-CARBONSAEUREAMIDE ALS GABA-REZEPTORLIGANDEN DES GEHIRNS
Title (fr)
4-OXO-NAPHTYRIDINE-3-CARBOXAMIDES SUBSTITUES COMME LIGANDS DE RECEPTEUR DE GABA DU CERVEAU
Publication
Application
Priority
- US 9817513 W 19980824
- US 91818097 A 19970825
Abstract (en)
[origin: WO9910347A1] The present invention encompasses structures of Formula (I) or the pharmaceutically acceptable non-toxic salts thereof wherein: X is hydrogen, halogen, (un)substituted alkyl, (un)substituted alkoxy or amino; and Y is (un)substituted alkyl, aryl, or heteroaryl, which compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAa brain receptors. These compounds are useful in the diagnosis and treatment of anxiety, Down Syndrome, sleep, cognitive and seizure disorders, and overdose with benzodiazepine drugs and for enhancement of alertness.
IPC 1-7
IPC 8 full level
A61K 31/4375 (2006.01); A61K 31/496 (2006.01); A61P 21/02 (2006.01); A61P 25/08 (2006.01); A61P 25/20 (2006.01); A61P 25/22 (2006.01); C07D 471/04 (2006.01)
IPC 8 main group level
C07D 221/00 (2006.01)
CPC (source: EP KR)
A61P 21/02 (2018.01 - EP); A61P 25/00 (2018.01 - EP); A61P 25/08 (2018.01 - EP); A61P 25/20 (2018.01 - EP); A61P 25/22 (2018.01 - EP); C07D 471/04 (2013.01 - EP KR)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9910347 A1 19990304; AP 2000001742 A0 20000224; AU 753800 B2 20021031; AU 9117398 A 19990316; BG 104192 A 20010531; BR 9811362 A 20000822; CA 2301599 A1 19990304; CA 2301599 C 20030325; CN 1268136 A 20000927; EG 21717 A 20020227; EP 1007526 A1 20000614; HU P0003258 A2 20010328; HU P0003258 A3 20010528; IL 134291 A0 20010430; IS 5382 A 20000222; JP 2001514181 A 20010911; KR 20010023313 A 20010326; LV 12539 A 20001020; LV 12539 B 20010120; NO 20000822 D0 20000218; NO 20000822 L 20000413; NZ 502548 A 20020628; OA 11293 A 20021119; PE 130999 A1 19991216; PL 338783 A1 20001120; SI 20270 A 20001231; SK 2162000 A3 20010312; TW 574221 B 20040201; YU 10500 A 20021018
DOCDB simple family (application)
US 9817513 W 19980824; AP 2000001742 A 20000201; AU 9117398 A 19980824; BG 10419200 A 20000225; BR 9811362 A 19980824; CA 2301599 A 19980824; CN 98808578 A 19980824; EG 118098 A 19980929; EP 98943352 A 19980824; HU P0003258 A 19980824; IL 13429198 A 19980824; IS 5382 A 20000222; JP 2000507675 A 19980824; KR 20007001948 A 20000225; LV 000029 A 20000316; NO 20000822 A 20000218; NZ 50254898 A 19980824; OA 1200000044 A 20000218; PE 00110098 A 19981113; PL 33878398 A 19980824; SI 9820055 A 19980824; SK 2162000 A 19980824; TW 87117597 A 19981023; YU 10500 A 19980824