Global Patent Index - EP 1007635 A1

EP 1007635 A1 2000-06-14 - AGENT FOR DEHYDRATING CORNEAS IN ORGAN CULTURE

Title (en)

AGENT FOR DEHYDRATING CORNEAS IN ORGAN CULTURE

Title (de)

MITTEL ZUR ENTQUELLUNG VON HORNHÄUTEN IN DER ORGANKULTUR

Title (fr)

AGENT DE DESHYDRATATION DE CORNEES EN CULTURE D'ORGANES

Publication

EP 1007635 A1 (DE)

Application

EP 98904113 A

Priority

  • DE 19702210 A
  • EP 9800324 W

Abstract (en)

[origin: DE19702210A1] An agent for dehydrating corneas, in particular eye corneas for organ culture, contains the culture medium and as dehydrating substance hydroxyethylstarch with a mean molecular weight MW from 70,000 to 200,000, an MS substitution degree from 0.15 to 0.5, a DS substitution degree from 0.15 to 0.5 and a C2-C6 substitution ratio at the anhydroglucose units >/= 8. The dehydrating substance is preferably hydroxyethylstarch with a mean molecular weight MW 130,000 +/- 20,000, an MS substitution degree from 0.38 to 0.45, a DS substitution degree from 0.32 to 0.40 and a C2-C6 substitution ratio at the anhydroglucose units from 8 to 20. The hydroxyethylstarch is used in a concentration from 1 to 20 (weight/vol.) %, preferably from 2 to 15 (weight/vol.) %, and in particular of 7.5 % (weight/vol.). Also disclosed is the use of this hydroxyethylstarch as a dehydrating substance for the organ culture of corneas, in particular eye corneas, and the use of this hydroxyethylstarch for preparing a dehydrating agent for corneas, in particular eye corneas for organ culture.

IPC 1-7 (main, further and additional classification)

C12N 5/08; A01N 1/02; A61K 31/72

IPC 8 full level (invention and additional information)

C12N 5/06 (2006.01); A01N 1/02 (2006.01); A61L 27/00 (2006.01); C08B 31/02 (2006.01); C12N 5/08 (2006.01)

CPC (invention and additional information)

A01N 1/0205 (2013.01); A01N 1/02 (2013.01)

Citation (search report)

See references of WO 9832839A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

DE 19702210 A1 19980806; DE 19702210 C2 19990114; EP 1007635 A1 20000614; JP 2001510996 A 20010807; WO 9832839 A1 19980730

INPADOC legal status


2005-06-08 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20041124

2002-09-04 [RAP1] TRANSFER OF RIGHTS OF AN EP PUBLISHED APPLICATION

- Owner name: FRESENIUS AG

2000-06-14 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 19990818

2000-06-14 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE