EP 1007715 A2 20000614 - ADENOVIRUS VECTORS CONTAINING HETEROLOGOUS TRANSCRIPTION REGULATORY ELEMENTS AND METHODS OF USING SAME
Title (en)
ADENOVIRUS VECTORS CONTAINING HETEROLOGOUS TRANSCRIPTION REGULATORY ELEMENTS AND METHODS OF USING SAME
Title (de)
ADENOVIRALE VEKTOREN, DIE HETEROLOGE REGULATORISCHE ELEMENTE FÜR DIE TRANSKRIPTION ENTHALTEN UND METHODEN FÜR IHRE VERWENDUNG
Title (fr)
VECTEURS D'ADENOVIRUS CONTENANT DES ELEMENTS HETEROLOGUES REGULATEURS DE TRANSCRIPTION, ET LEUR PROCEDE D'UTILISATION
Publication
Application
Priority
- US 9804080 W 19980303
- US 3976297 P 19970303
- US 3976397 P 19970303
- US 5452397 P 19970804
- US 3355698 A 19980302
Abstract (en)
[origin: WO9839464A2] Replication-competent adenovirus vectors specific for target cells and methods of use of such viruses are provided. These adenoviruses comprise a first adenoviral gene under control of a cell specific heterologous (i.e., non-adenoviral) transcriptional regulatory element (TRE) and at least a second gene under control of a second heterologous TRE, where the heterologous TREs are different from each other in polynucleotide sequence but functional in the same cell. The adenoviral gene can be, for example, a gene required for adenoviral replication. The second gene can be, for example, a second adenoviral gene or a transgene, such as a gene which can contribute to cytotoxicity in the target cell. Adenoviral replication can be restricted to target cells in which the heterologous TREs are functional and thus, the adenovirus vectors can provide selective cytotoxicity to the target cells, particularly neoplastic cells.
IPC 1-7
IPC 8 full level
C12N 15/09 (2006.01); A61K 35/76 (2006.01); A61K 35/761 (2015.01); A61K 47/48 (2006.01); A61K 48/00 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07K 14/075 (2006.01); C12N 5/10 (2006.01); C12N 7/00 (2006.01); C12N 11/08 (2006.01); C12N 15/86 (2006.01); C12N 15/861 (2006.01)
CPC (source: EP)
A61K 35/761 (2013.01); A61K 47/6901 (2017.07); A61P 35/00 (2017.12); A61P 43/00 (2017.12); C12N 7/00 (2013.01); C12N 15/86 (2013.01); A61K 48/00 (2013.01); C12N 2710/10322 (2013.01); C12N 2710/10332 (2013.01); C12N 2710/10343 (2013.01); C12N 2830/00 (2013.01); C12N 2830/002 (2013.01); C12N 2830/008 (2013.01); C12N 2830/85 (2013.01)
Citation (search report)
See references of WO 9839464A2
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9839464 A2 19980911; WO 9839464 A3 19990107; WO 9839464 A8 19990401; AU 6345098 A 19980922; AU 744725 B2 20020228; CA 2283231 A1 19980911; CA 2283231 C 20080520; EP 1007715 A2 20000614; JP 2002514074 A 20020514
DOCDB simple family (application)
US 9804080 W 19980303; AU 6345098 A 19980303; CA 2283231 A 19980303; EP 98907702 A 19980303; JP 53867498 A 19980303