EP 1007967 A2 20000614 - METHODS FOR IDENTIFYING LIGAND SPECIFIC BINDING MOLECULES
Title (en)
METHODS FOR IDENTIFYING LIGAND SPECIFIC BINDING MOLECULES
Title (de)
VERFAHREN ZUR IDENTIFIZIERUNG LIGANDSPEZIFISCHER BINDUNGSMOLEKÜLE
Title (fr)
PROCEDES PERMETTANT D'IDENTIFIER DES MOLECULES DE LIAISON PRESENTANT UNE AFFINITE SPECIFIQUE POUR DES LIGANDS
Publication
Application
Priority
- US 9816280 W 19980804
- US 90582597 A 19970804
Abstract (en)
[origin: WO9906834A2] The present invention provides a method for identifying a binding molecule having selective affinity for a ligand. The method consists of selectively immobilizing a diverse population of binding molecules to a solid support, simultaneously contacting the diverse population immobilized on the solid support with two or more ligands and determining at least one binding molecule which selectively binds to one or more of the ligands. The invention additionally provides a method for identifying an antibody having selective affinity for a tumor antigen. The method consists of selectively immobilizing a diverse population of antibodies to a solid support, simultaneously contacting the diverse population immobilized on the solid support with two or more tumor antigens and determining at least one antibody which selectively binds to one or more of the tumor antigens. The invention also provides an isolated binding polypeptide selective for a tumor antigen. Further provided by the present invention is a Complementarity Determining Region (CDR) or functional fragment thereof of an antibody selective for a tumor antigen.
IPC 1-7
IPC 8 full level
C07K 16/00 (2006.01); C07K 16/30 (2006.01); G01N 33/68 (2006.01)
CPC (source: EP)
C07K 16/00 (2013.01); C07K 16/30 (2013.01); G01N 33/6857 (2013.01)
Citation (search report)
See references of WO 9906834A2
Designated contracting state (EPC)
CH DE FR GB LI
DOCDB simple family (publication)
WO 9906834 A2 19990211; WO 9906834 A3 19990514; AU 8691398 A 19990222; EP 1007967 A2 20000614
DOCDB simple family (application)
US 9816280 W 19980804; AU 8691398 A 19980804; EP 98938377 A 19980804