Global patent index - EP 1009401 A1

EP 1009401 A1 2000-06-21 - DITHIOLOPYRROLONES AND THEIR CORRESPONDING MONOXIDES AND DIOXIDES AS ANTINEOPLASTIC AGENTS

Title (en)

DITHIOLOPYRROLONES AND THEIR CORRESPONDING MONOXIDES AND DIOXIDES AS ANTINEOPLASTIC AGENTS

Title (de)

DITHIOLOPYRROLONE SOWIE DEREN MONOXIDE UND DIOXIDE ALS ANTINEOPLASTISCHE MITTEL

Title (fr)

DITHIOLOPYRROLONES ET LEURS MONOXYDES ET DIOXYDES CORRESPONDANTS COMME AGENTS ANTINEOPLASIQUES

Publication

EP 1009401 A1 (EN)

Application

EP 98942414 A

Priority

  • CA 9800841 W
  • CA 2212237 A

Abstract (en)

[origin: WO9912543A1] Compounds, isolated from the bacteria Xenorhabdus bovienii, having formula (1), wherein R1 = hydrogen, substituted or unsubstituted alkyl, cycloalkyl, aryl, aralkyl, or heterocyclyl group; R2 = hydrogen, substituted or unsubstituted alkyl, cycloalkyl, aryl, aralkyl, heterocyclyl or group acyl; R3 = hydrogen, alkyl, cycloalkyl, aralkyl, aryl or heterocyclyl group, or (2), wherein R1 = hydrogen, substituted or unsubstituted alkyl, cycloalkyl, aryl, aralkyl, or heterocyclyl group; R2 = hydrogen, substituted or unsubstituted alkyl, cycloalkyl, aryl, aralkyl, heterocyclyl or group acyl; R3 = hydrogen, alkyl, cycloalkyl, aralkyl, aryl or heterocyclyl group, or (3), wherein R1 = hydrogen, substituted or unsubstituted alkyl, cycloalkyl, aryl, aralkyl, or heterocyclyl group; R2 = hydrogen, substituted or unsubstituted alkyl, cycloalkyl, aryl, aralkyl, heterocyclyl or group acyl; R3 = hydrogen, alkyl, cycloalkyl, aralkyl, aryl or heterocyclyl group or the salts thereof have antineoplastic activity. The invention provides pharmaceutical compositions containing the compounds and the methods for employing them as medicaments, particularly in the treatment of human and animal cancers.

IPC 1-7 (main, further and additional classification)

A61K 31/40; C07D 495/04

IPC 8 full level (invention and additional information)

C12P 17/18 (2006.01); A61K 31/407 (2006.01); A61P 35/00 (2006.01); C07D 495/04 (2006.01)

CPC (invention and additional information)

C07D 495/04 (2013.01); A61K 31/407 (2013.01)

Citation (search report)

See references of WO 9912543A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9912543 A1 19990318; AU 759990 B2 20030501; AU 9057098 A 19990329; CA 2212237 A1 19990305; CN 1276723 A 20001213; CN 1360891 A 20020731; EP 1009401 A1 20000621; JP 2001515861 A 20010925

INPADOC legal status

2004-01-28 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20030711

2003-04-16 [17Q] FIRST EXAMINATION REPORT

- Ref Legal Event Code: 17Q

- Effective date: 20030228

2003-01-08 [RAP1] TRANSFER OF RIGHTS OF AN EP PUBLISHED APPLICATION

- Owner name: WELICHEM BIOTECH INC.

- Ref Legal Event Code: RAP1

2000-06-21 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20000405

2000-06-21 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE