Global Patent Index - EP 1009405 A1

EP 1009405 A1 2000-06-21 - PYRROLIDINE AND PIPERIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY

Title (en)

PYRROLIDINE AND PIPERIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY

Title (de)

PAYRROLIDINE UND PIPERIDINE MODULATOREN DER CHEMOKINE REZEPTORAKTIVITAET

Title (fr)

MODULATEURS DE PYRROLIDINE ET DE PIPERIDINE DE L'ACTIVITE DU RECEPTEUR DE CHEMOKINE

Publication

EP 1009405 A1 (EN)

Application

EP 98944548 A

Priority

  • GB 9801009 A
  • US 9817755 W
  • US 5774397 P

Abstract (en)

[origin: WO9909984A1] The present invention is directed to pyrrolidine and piperidine compounds of formula (I), (wherein R<1>, R<2>, R<3>, R<4a>, R<4b>, R<4c>, R<4d>, R<4e>, R<4f>, R<4g>, R<4h>, m, n, x and y are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-1, CCR-2, CCR-2A, CCR-2B, CCR-3, CCR-4, CCR-5, CXCR-3, and/or CXCR-4.

IPC 1-7 (main, further and additional classification)

A61K 31/47; A61K 31/435; A61K 31/445; A61K 31/495; A61K 31/55; C07D 211/68; C07D 217/02; C07D 223/16; C07D 401/06; C07D 403/06

IPC 8 full level (invention and additional information)

C07D 217/02 (2006.01); A61K 31/40 (2006.01); A61K 31/435 (2006.01); A61K 31/438 (2006.01); A61K 31/4427 (2006.01); A61K 31/443 (2006.01); A61K 31/4433 (2006.01); A61K 31/451 (2006.01); A61K 31/454 (2006.01); A61K 31/4545 (2006.01); A61K 31/47 (2006.01); A61K 31/4709 (2006.01); A61K 31/472 (2006.01); A61K 31/4725 (2006.01); A61K 31/496 (2006.01); A61K 31/55 (2006.01); A61P 29/00 (2006.01); A61P 31/18 (2006.01); A61P 37/00 (2006.01); C07D 207/09 (2006.01); C07D 211/14 (2006.01); C07D 211/70 (2006.01); C07D 211/96 (2006.01); C07D 223/02 (2006.01); C07D 223/16 (2006.01); C07D 401/06 (2006.01); C07D 401/14 (2006.01); C07D 403/06 (2006.01); C07D 405/14 (2006.01); C07D 409/14 (2006.01); C07D 413/14 (2006.01); C07D 417/14 (2006.01); C07D 495/10 (2006.01)

CPC (invention and additional information)

C07D 401/06 (2013.01); C07D 401/14 (2013.01); C07D 403/06 (2013.01); C07D 405/14 (2013.01); C07D 409/14 (2013.01); C07D 495/10 (2013.01)

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

EPO simple patent family

WO 9909984 A1 19990304; AU 9206798 A 19990316; CA 2298813 A1 19990304; EP 1009405 A1 20000621; EP 1009405 A4 20010509; JP 2001526178 A 20011218

INPADOC legal status


2002-10-09 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20020301

2001-05-09 [A4] SUPPLEMENTARY SEARCH REPORT

- Ref Legal Event Code: A4

- Effective date: 20010327

2001-05-09 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

2001-05-09 [RIC1] CLASSIFICATION (CORRECTION)

- Ref Legal Event Code: RIC1

- Free Format Text: 7A 61K 31/47 A, 7A 61K 31/55 B, 7A 61K 31/435 B, 7A 61K 31/445 B, 7A 61K 31/495 B, 7C 07D 211/68 B, 7C 07D 217/02 B, 7C 07D 223/16 B, 7C 07D 401/06 B, 7C 07D 403/06 B, 7C 07D 495/10 B, 7C 07D 409/14 B, 7C 07D 401/14 B, 7C 07D 417/14 B, 7C 07D 413/14 B, 7C 07D 207/09 B, 7C 07D 405/14 B, 7A 61P 31/18 B, 7C 07D 211/26 B

2000-06-21 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20000328

2000-06-21 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

2000-06-21 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Ref Legal Event Code: AX

- Free Format Text: AL PAYMENT 20000328;LT PAYMENT 20000328;LV PAYMENT 20000328;MK PAYMENT 20000328;RO PAYMENT 20000328;SI PAYMENT 20000328