EP 1009431 A4 20000927 - HUMAN TUMOR NECROSIS FACTOR RECEPTOR-LIKE 2 (TR2) ANTIBODIES
Title (en)
HUMAN TUMOR NECROSIS FACTOR RECEPTOR-LIKE 2 (TR2) ANTIBODIES
Title (de)
ANTIKÖRPER GEGEN DEN MENSCHLICHEN TUMORNEKROSEFAKTOR-REZEPTOR DES TYPS 2 (TR2)
Title (fr)
ANTICORPS CONTRE LE RECEPTEUR DE TYPE 2 (TR2) DU FACTEUR DE NECROSE DES TUMEURS HUMAIN
Publication
Application
Priority
- US 9809744 W 19980512
- US 4624997 P 19970512
Abstract (en)
[origin: WO9851346A1] The present invention relates to antibodies to novel members of the Tumor Necrosis Factor (TNF) receptor family called TR2 receptor and their uses in pathological conditions. Hybridoma cell lines producing such mAbs, methods of in vivo imaging of pathological conditions, and methods of treating and diagnosing pathological conditions, caused by abnormal functioning, production or metabolism of TR2 receptors are also provided. In vitro assays for detecting the presence of TR2 and for evaluating the binding affinity of a test compound are also described.
IPC 1-7
IPC 8 full level
A61K 39/395 (2006.01); A61P 11/06 (2006.01); A61P 17/00 (2006.01); A61P 37/08 (2006.01); A61P 43/00 (2006.01); C07K 16/28 (2006.01); G01N 33/68 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
A61P 11/06 (2017.12); A61P 17/00 (2017.12); A61P 37/08 (2017.12); A61P 43/00 (2017.12); C07K 16/2878 (2013.01); G01N 33/6863 (2013.01); A61K 38/00 (2013.01)
Citation (search report)
- [A] WO 9634095 A1 19961031 - HUMAN GENOME SCIENCES INC [US], et al
- [A] WO 9409137 A1 19940428 - GENENTECH INC [US]
- [A] WO 9704658 A1 19970213 - UNIV NORTHWESTERN [US], et al
- [A] B. KWON ET AL.: "A newly-identified member of the tumor necrosis factor receptor superfamily.", THE JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol. 99, no. 1 part 2, January 1997 (1997-01-01), St. Louis, MO, USA, pages S467, XP000929446
- [T] J. HARROP ET AL.: "Antibodies to TR2 (herpesvirus entry mediator), a new member of the TNF receptor superfamily, block T cell proliferation, expression of activation markers, and production of cytokines.", THE JOURNAL OF IMMUNOLOGY, vol. 161, no. 4, 15 August 1998 (1998-08-15), Baltimore, MD, USA, pages 1786 - 1794, XP002143292
- See references of WO 9851346A1
Designated contracting state (EPC)
BE CH DE DK FR GB IT LI NL
DOCDB simple family (publication)
WO 9851346 A1 19981119; CA 2290067 A1 19981119; EP 1009431 A1 20000621; EP 1009431 A4 20000927; JP 2001524985 A 20011204
DOCDB simple family (application)
US 9809744 W 19980512; CA 2290067 A 19980512; EP 98922245 A 19980512; JP 54948198 A 19980512