EP 1009441 A1 20000621 - METHOD FOR THE TREATMENT OF GRAFTS
Title (en)
METHOD FOR THE TREATMENT OF GRAFTS
Title (de)
VERFAHREN ZUR BEHANDLUNG VON TRANSPLANTATEN
Title (fr)
PROCEDE DE TRAITEMENT DES GREFFONS
Publication
Application
Priority
- US 9815971 W 19980731
- US 5438697 P 19970731
Abstract (en)
[origin: WO9906073A1] The present invention provides a method for treatment of grafts which comprises introducing a nucleic acid encoding an angiogenic agent into the cells of the graft. The graft may be treated ex vivo and then transplanted into the donor or may be treated after transplantation. The graft may be autologous, allogenic, xenogenic or a tissue engineered graft ("bio-artifical" organ). The nucleic acid may be introduced to the cultured cells used to form the tissue engineered graft. Expression of the angiogenic agent by the cells of the graft promotes growth of new blood vessels (angiogenesis) providing the graft with a blood supply thus increasing the chances for graft survival.
IPC 1-7
IPC 8 full level
C12N 15/09 (2006.01); A61K 38/18 (2006.01); A61K 48/00 (2006.01); A61P 37/06 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
A61K 35/36 (2013.01); A61K 38/1866 (2013.01); A61P 37/06 (2017.12); A61K 48/00 (2013.01)
C-Set (source: EP)
Citation (search report)
See references of WO 9906073A1
Designated contracting state (EPC)
DE FR GB IT
DOCDB simple family (publication)
WO 9906073 A1 19990211; AU 8763898 A 19990222; CA 2298811 A1 19990211; EP 1009441 A1 20000621; JP 2001511462 A 20010814
DOCDB simple family (application)
US 9815971 W 19980731; AU 8763898 A 19980731; CA 2298811 A 19980731; EP 98939149 A 19980731; JP 2000504884 A 19980731