EP 1009807 A1 20000621 - DIFFERENTIAL LIGAND ACTIVATION OF ESTROGEN RECEPTORS ER ALPHA AND ER BETA AT AP1 SITES
Title (en)
DIFFERENTIAL LIGAND ACTIVATION OF ESTROGEN RECEPTORS ER ALPHA AND ER BETA AT AP1 SITES
Title (de)
DIFFERENTIELLE LIGANDAKTIVIERUNG DES ÖSTROGENREZEPTORS ER ALPHA UND ER BETA AN DER AP1 BINDUNGSSTELLE
Title (fr)
ACTIVATION DIFFERENTIELLE DES LIGANDS DES RECEPTEURS ER ALPHA ET ER BETA DE L'OESTROGENE DANS LES SITES AP1
Publication
Application
Priority
- US 9818030 W 19980831
- US 92370897 A 19970904
Abstract (en)
[origin: WO9911760A1] This invention provides methods of screening test compounds for the ability to activate or inhibit estrogen receptor beta (ER beta ) mediated gene activation at an AP1 site. In particular, the methods involve providing a cell comprising an estrogen receptor beta (ER beta ), AP1 proteins, and a construct comprising a promoter comprising an AP1 site which regulates expression of a first reporter gene. The cell is contacted with the test compound and changes in expression levels of the reporter gene are detected indicating whether the test compounds activate transcription, inactivate transcription or have no effect at the AP1 site.
IPC 1-7
IPC 8 full level
G01N 33/50 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12Q 1/66 (2006.01); C12Q 1/68 (2006.01); G01N 33/15 (2006.01); G01N 33/53 (2006.01); G01N 33/566 (2006.01); G01N 33/74 (2006.01)
CPC (source: EP)
C12Q 1/6897 (2013.01); G01N 33/743 (2013.01); G01N 2333/723 (2013.01); G01N 2500/20 (2013.01)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9911760 A1 19990311; AU 757348 B2 20030220; AU 8924398 A 19990322; CA 2301143 A1 19990311; EP 1009807 A1 20000621; EP 1009807 A4 20041103; IL 134811 A0 20010430; JP 2001514843 A 20010918
DOCDB simple family (application)
US 9818030 W 19980831; AU 8924398 A 19980831; CA 2301143 A 19980831; EP 98941104 A 19980831; IL 13481198 A 19980831; JP 2000508772 A 19980831