Global Patent Index - EP 1009807 A1

EP 1009807 A1 2000-06-21 - DIFFERENTIAL LIGAND ACTIVATION OF ESTROGEN RECEPTORS ER ALPHA AND ER BETA AT AP1 SITES

Title (en)

DIFFERENTIAL LIGAND ACTIVATION OF ESTROGEN RECEPTORS ER ALPHA AND ER BETA AT AP1 SITES

Title (de)

DIFFERENTIELLE LIGANDAKTIVIERUNG DES ÖSTROGENREZEPTORS ER ALPHA UND ER BETA AN DER AP1 BINDUNGSSTELLE

Title (fr)

ACTIVATION DIFFERENTIELLE DES LIGANDS DES RECEPTEURS ER ALPHA ET ER BETA DE L'OESTROGENE DANS LES SITES AP1

Publication

EP 1009807 A1 (EN)

Application

EP 98941104 A

Priority

  • US 9818030 W
  • US 92370897 A

Abstract (en)

[origin: WO9911760A1] This invention provides methods of screening test compounds for the ability to activate or inhibit estrogen receptor beta (ER beta ) mediated gene activation at an AP1 site. In particular, the methods involve providing a cell comprising an estrogen receptor beta (ER beta ), AP1 proteins, and a construct comprising a promoter comprising an AP1 site which regulates expression of a first reporter gene. The cell is contacted with the test compound and changes in expression levels of the reporter gene are detected indicating whether the test compounds activate transcription, inactivate transcription or have no effect at the AP1 site.

IPC 1-7 (main, further and additional classification)

C12N 5/10; C12N 15/09; C12Q 1/68; G01N 33/53; G01N 33/566

IPC 8 full level (invention and additional information)

G01N 33/50 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12Q 1/66 (2006.01); C12Q 1/68 (2006.01); G01N 33/15 (2006.01); G01N 33/53 (2006.01); G01N 33/566 (2006.01); G01N 33/74 (2006.01)

CPC (invention and additional information)

C12Q 1/6897 (2013.01); G01N 33/743 (2013.01); G01N 2333/723 (2013.01); G01N 2500/20 (2013.01)

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9911760 A1 19990311; AU 757348 B2 20030220; AU 8924398 A 19990322; CA 2301143 A1 19990311; EP 1009807 A1 20000621; EP 1009807 A4 20041103; IL 134811 D0 20010430; JP 2001514843 A 20010918

INPADOC legal status


2006-06-28 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20051202

2005-04-06 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20050216

2004-11-24 [RTI1] TITLE (CORRECTION)

- Free text: DIFFERENTIAL LIGAND ACTIVATION OF ESTROGEN RECEPTORS ER ALPHA AND ER BETA AT AP1 SITES

2004-11-03 [A4] SUPPLEMENTARY SEARCH REPORT

- Effective date: 20040921

2004-10-13 [RIC1] CLASSIFICATION (CORRECTION)

- IPC: 7C 12N 5/10 A

2004-10-13 [RIC1] CLASSIFICATION (CORRECTION)

- IPC: 7C 12N 15/09 B

2004-10-13 [RIC1] CLASSIFICATION (CORRECTION)

- IPC: 7G 01N 33/53 B

2004-10-13 [RIC1] CLASSIFICATION (CORRECTION)

- IPC: 7G 01N 33/566 B

2004-10-13 [RIC1] CLASSIFICATION (CORRECTION)

- IPC: 7C 12Q 1/68 B

2000-10-11 [RIN1] INVENTOR (CORRECTION)

- Inventor name: KUSHNER, PETER, J.

2000-10-11 [RIN1] INVENTOR (CORRECTION)

- Inventor name: GUSTAFSSON, JAN-AKE

2000-10-11 [RIN1] INVENTOR (CORRECTION)

- Inventor name: KUIPER, GEORGE, G., J., M.

2000-10-11 [RIN1] INVENTOR (CORRECTION)

- Inventor name: NILSSON, STEFAN

2000-10-11 [RIN1] INVENTOR (CORRECTION)

- Inventor name: PAECH, KOLJA UNIVERSITY OF CALIFORNIA

2000-10-11 [RIN1] INVENTOR (CORRECTION)

- Inventor name: SCANLAN, THOMAS, S.

2000-10-11 [RIN1] INVENTOR (CORRECTION)

- Inventor name: WEBB, PAUL

2000-06-21 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000315

2000-06-21 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE