Global Patent Index - EP 1009807 A1

EP 1009807 A1 20000621 - DIFFERENTIAL LIGAND ACTIVATION OF ESTROGEN RECEPTORS ER ALPHA AND ER BETA AT AP1 SITES

Title (en)

DIFFERENTIAL LIGAND ACTIVATION OF ESTROGEN RECEPTORS ER ALPHA AND ER BETA AT AP1 SITES

Title (de)

DIFFERENTIELLE LIGANDAKTIVIERUNG DES ÖSTROGENREZEPTORS ER ALPHA UND ER BETA AN DER AP1 BINDUNGSSTELLE

Title (fr)

ACTIVATION DIFFERENTIELLE DES LIGANDS DES RECEPTEURS ER ALPHA ET ER BETA DE L'OESTROGENE DANS LES SITES AP1

Publication

EP 1009807 A1 20000621 (EN)

Application

EP 98941104 A 19980831

Priority

  • US 9818030 W 19980831
  • US 92370897 A 19970904

Abstract (en)

[origin: WO9911760A1] This invention provides methods of screening test compounds for the ability to activate or inhibit estrogen receptor beta (ER beta ) mediated gene activation at an AP1 site. In particular, the methods involve providing a cell comprising an estrogen receptor beta (ER beta ), AP1 proteins, and a construct comprising a promoter comprising an AP1 site which regulates expression of a first reporter gene. The cell is contacted with the test compound and changes in expression levels of the reporter gene are detected indicating whether the test compounds activate transcription, inactivate transcription or have no effect at the AP1 site.

IPC 1-7

C12N 5/10; C12N 15/09; G01N 33/53; G01N 33/566; C12Q 1/68

IPC 8 full level

G01N 33/50 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12Q 1/66 (2006.01); C12Q 1/68 (2006.01); G01N 33/15 (2006.01); G01N 33/53 (2006.01); G01N 33/566 (2006.01); G01N 33/74 (2006.01)

CPC (source: EP)

C12Q 1/6897 (2013.01); G01N 33/743 (2013.01); G01N 2333/723 (2013.01); G01N 2500/20 (2013.01)

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9911760 A1 19990311; AU 757348 B2 20030220; AU 8924398 A 19990322; CA 2301143 A1 19990311; EP 1009807 A1 20000621; EP 1009807 A4 20041103; IL 134811 A0 20010430; JP 2001514843 A 20010918

DOCDB simple family (application)

US 9818030 W 19980831; AU 8924398 A 19980831; CA 2301143 A 19980831; EP 98941104 A 19980831; IL 13481198 A 19980831; JP 2000508772 A 19980831