EP 1009854 A1 20000621 - A METHOD OF TREATING CANCER
Title (en)
A METHOD OF TREATING CANCER
Title (de)
EINE METHODE ZUR BEHANDLUNG VON KREBS
Title (fr)
PROCEDE DE TRAITEMENT DU CANCER
Publication
Application
Priority
- GB 9724331 A 19971118
- US 9817697 W 19980826
- US 5734097 P 19970827
Abstract (en)
[origin: WO9910523A1] The instant invention provides for a method of inhibiting prenyl-protein transferases and treating cancer which comprises administering to a mammal a prenyl-protein transferase inhibitor which is efficacious in vivo as an inhibitor of geranylgeranyl-protein transferase type I (GGTase-I). The invention also provides for a method of inhibiting farnesyl-protein transferase and geranylgeranyl-protein transferase type I by administering a compound that is a dual inhibitor of both of those prenyl-protein transferases. The invention also provides for a method of identifying such a compound, the method comprising a modified inhibitory assay that incorporates a modulator anion that alters the in vitro potency of prenyl-protein transferase inhibitors in a way that predicts their potency in vivo, thus providing convenient identification of compounds that possess such in vivo activity.
IPC 1-7
C12Q 1/48; C12N 9/10; A01N 43/40; A01N 43/50; A01N 43/62; A61K 31/55; A61K 31/415; A61K 31/445
IPC 8 full level
A01N 43/40 (2006.01); A01N 43/50 (2006.01); A01N 43/62 (2006.01); A61K 31/00 (2006.01); A61K 31/4174 (2006.01); A61K 31/4178 (2006.01); A61K 31/4427 (2006.01); A61K 31/4439 (2006.01); A61K 31/445 (2006.01); A61K 31/454 (2006.01); A61K 31/495 (2006.01); A61K 31/496 (2006.01); A61K 31/5513 (2006.01); A61K 38/00 (2006.01); A61K 38/05 (2006.01); A61K 45/00 (2006.01); C07D 233/64 (2006.01); C07D 233/88 (2006.01); C07D 241/04 (2006.01); C07D 401/12 (2006.01); C07D 403/06 (2006.01); C07D 403/12 (2006.01); C07D 403/14 (2006.01); C12N 9/10 (2006.01); C12N 9/99 (2006.01); C12Q 1/48 (2006.01); G01N 33/50 (2006.01)
CPC (source: EP)
A61K 31/00 (2013.01); A61K 31/4174 (2013.01); A61K 31/4178 (2013.01); A61K 31/4439 (2013.01); A61K 31/454 (2013.01); A61K 31/495 (2013.01); A61K 31/496 (2013.01); A61K 31/5513 (2013.01); A61K 38/005 (2013.01); A61K 38/05 (2013.01); C12N 9/99 (2013.01); C12Q 1/48 (2013.01); G01N 33/5011 (2013.01)
Citation (search report)
See references of WO 9910523A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
WO 9910523 A1 19990304; AU 9205898 A 19990316; CA 2301877 A1 19990304; EP 1009854 A1 20000621; JP 2001518281 A 20011016
DOCDB simple family (application)
US 9817697 W 19980826; AU 9205898 A 19980826; CA 2301877 A 19980826; EP 98944537 A 19980826; JP 2000507831 A 19980826