Global Patent Index - EP 1009854 A1

EP 1009854 A1 2000-06-21 - A METHOD OF TREATING CANCER

Title (en)

A METHOD OF TREATING CANCER

Title (de)

EINE METHODE ZUR BEHANDLUNG VON KREBS

Title (fr)

PROCEDE DE TRAITEMENT DU CANCER

Publication

EP 1009854 A1 (EN)

Application

EP 98944537 A

Priority

  • GB 9724331 A
  • US 9817697 W
  • US 5734097 P

Abstract (en)

[origin: WO9910523A1] The instant invention provides for a method of inhibiting prenyl-protein transferases and treating cancer which comprises administering to a mammal a prenyl-protein transferase inhibitor which is efficacious in vivo as an inhibitor of geranylgeranyl-protein transferase type I (GGTase-I). The invention also provides for a method of inhibiting farnesyl-protein transferase and geranylgeranyl-protein transferase type I by administering a compound that is a dual inhibitor of both of those prenyl-protein transferases. The invention also provides for a method of identifying such a compound, the method comprising a modified inhibitory assay that incorporates a modulator anion that alters the in vitro potency of prenyl-protein transferase inhibitors in a way that predicts their potency in vivo, thus providing convenient identification of compounds that possess such in vivo activity.

IPC 1-7 (main, further and additional classification)

C12Q 1/48; A01N 43/40; A01N 43/50; A01N 43/62; A61K 31/415; A61K 31/445; A61K 31/55; C12N 9/10

IPC 8 full level (invention and additional information)

C12N 9/10 (2006.01); A01N 43/40 (2006.01); A01N 43/50 (2006.01); A01N 43/62 (2006.01); A61K 31/00 (2006.01); A61K 31/4174 (2006.01); A61K 31/4178 (2006.01); A61K 31/4427 (2006.01); A61K 31/4439 (2006.01); A61K 31/445 (2006.01); A61K 31/454 (2006.01); A61K 31/495 (2006.01); A61K 31/496 (2006.01); A61K 31/5513 (2006.01); A61K 38/00 (2006.01); A61K 38/05 (2006.01); A61K 45/00 (2006.01); C07D 233/64 (2006.01); C07D 233/88 (2006.01); C07D 241/04 (2006.01); C07D 401/12 (2006.01); C07D 403/06 (2006.01); C07D 403/12 (2006.01); C07D 403/14 (2006.01); C12N 9/99 (2006.01); C12Q 1/48 (2006.01); G01N 33/50 (2006.01)

CPC (invention and additional information)

G01N 33/5011 (2013.01); A61K 31/00 (2013.01); A61K 31/4174 (2013.01); A61K 31/4178 (2013.01); A61K 31/4439 (2013.01); A61K 31/454 (2013.01); A61K 31/495 (2013.01); A61K 31/496 (2013.01); A61K 31/5513 (2013.01); A61K 38/005 (2013.01); A61K 38/05 (2013.01); C12N 9/99 (2013.01); C12Q 1/48 (2013.01)

Citation (search report)

See references of WO 9910523A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

EPO simple patent family

WO 9910523 A1 19990304; AU 9205898 A 19990316; CA 2301877 A1 19990304; EP 1009854 A1 20000621; JP 2001518281 A 20011016

INPADOC legal status


2002-10-23 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20020301

2000-06-21 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000327

2000-06-21 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

2000-06-21 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Free text: AL PAYMENT 20000327;LT PAYMENT 20000327;LV PAYMENT 20000327;MK PAYMENT 20000327;RO PAYMENT 20000327;SI PAYMENT 20000327