EP 1011328 A1 20000628 - STIMULATION, MODULATION AND/OR INHIBITION OF ENDOTHELIAL PROTEOLYTIC ACTIVITY AND/OR ANGIOGENIC ACTIVITY

Title (en)

STIMULATION, MODULATION AND/OR INHIBITION OF ENDOTHELIAL PROTEOLYTIC ACTIVITY AND/OR ANGIOGENIC ACTIVITY

Title (de)

STIMULIERUNG, MODULIERUNGUND/ODER HEMMUNG DER ENDOTHELIALEN PROTEOLYTISCHEN AKTIVITÄT UND/ODER ANIGIOGENEN AKTIVITÄT

Title (fr)

STIMULATION MODULATION ET/OU INHIBITION DE L'ACTIVITE PROTHEOLITHIQUE ENDOTHELIALE ET/OU DE L'ACTIVITE ANGIOGINIQUE

Publication

EP 1011328 A1 20000628 (EN)

Application

EP 98940875 A 19980814

Priority

US 9816816 W 19980814
US 5586897 P 19970815

Abstract (en)

[origin: WO9908522A1] Vascular endothelial growth factor-B (VEGF-B) and vascular endothelial growth factor-C (VEGF-C) are angiogenic polypeptides. It has been shown that VEGF-B and -C are angiogenic in vitro especially in combination with bFGF. VEGF-C also increases plasminogen activator (PA) activity in bovine endothelial cell lines and this is accompanied by a concomitant increase in PA inhibitor-1. Addition of alpha-2-antiplasmin to bovine endothelial cells co-treated with bFGF and VEGF-C partially inhibits collagen gel invasion.

IPC 1-7

A01N 37/18

IPC 8 full level

A61K 38/19 (2006.01); A61K 38/57 (2006.01); C07K 14/50 (2006.01); C07K 14/52 (2006.01); C07K 14/81 (2006.01); C07K 16/22 (2006.01); C07K 16/24 (2006.01); C12N 5/06 (2006.01); C12N 5/07 (2010.01); C12N 5/071 (2010.01); C12N 15/09 (2006.01); C12N 15/12 (2006.01); C12Q 1/68 (2006.01); A61K 38/00 (2006.01)

CPC (source: EP KR)

A61K 38/1866 (2013.01 - EP KR); C07K 14/503 (2013.01 - EP KR); C07K 14/52 (2013.01 - EP KR); C07K 14/8121 (2013.01 - EP); C07K 16/22 (2013.01 - EP KR); C07K 16/24 (2013.01 - EP KR)

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9908522 A1 19990225; AU 8905698 A 19990308; CA 2300964 A1 19990225; CN 1275050 A 20001129; EP 1011328 A1 20000628; EP 1011328 A4 20010516; JP 2001514867 A 20010918; KR 20010022887 A 20010326

DOCDB simple family (application)

US 9816816 W 19980814; AU 8905698 A 19980814; CA 2300964 A 19980814; CN 98810009 A 19980814; EP 98940875 A 19980814; JP 2000509282 A 19980814; KR 20007001491 A 20000214