Global Patent Index - EP 1011328 A1

EP 1011328 A1 2000-06-28 - STIMULATION, MODULATION AND/OR INHIBITION OF ENDOTHELIAL PROTEOLYTIC ACTIVITY AND/OR ANGIOGENIC ACTIVITY

Title (en)

STIMULATION, MODULATION AND/OR INHIBITION OF ENDOTHELIAL PROTEOLYTIC ACTIVITY AND/OR ANGIOGENIC ACTIVITY

Title (de)

STIMULIERUNG, MODULIERUNGUND/ODER HEMMUNG DER ENDOTHELIALEN PROTEOLYTISCHEN AKTIVITÄT UND/ODER ANIGIOGENEN AKTIVITÄT

Title (fr)

STIMULATION MODULATION ET/OU INHIBITION DE L'ACTIVITE PROTHEOLITHIQUE ENDOTHELIALE ET/OU DE L'ACTIVITE ANGIOGINIQUE

Publication

EP 1011328 A1 (EN)

Application

EP 98940875 A

Priority

  • US 9816816 W
  • US 5586897 P

Abstract (en)

[origin: WO9908522A1] Vascular endothelial growth factor-B (VEGF-B) and vascular endothelial growth factor-C (VEGF-C) are angiogenic polypeptides. It has been shown that VEGF-B and -C are angiogenic in vitro especially in combination with bFGF. VEGF-C also increases plasminogen activator (PA) activity in bovine endothelial cell lines and this is accompanied by a concomitant increase in PA inhibitor-1. Addition of alpha-2-antiplasmin to bovine endothelial cells co-treated with bFGF and VEGF-C partially inhibits collagen gel invasion.

IPC 1-7 (main, further and additional classification)

A01N 37/18

IPC 8 full level (invention and additional information)

C12N 15/09 (2006.01); A61K 38/19 (2006.01); A61K 38/57 (2006.01); C07K 14/50 (2006.01); C07K 14/52 (2006.01); C07K 14/81 (2006.01); C07K 16/22 (2006.01); C07K 16/24 (2006.01); C12N 5/06 (2006.01); C12N 15/12 (2006.01); C12Q 1/68 (2006.01); A61K 38/00 (2006.01)

CPC (invention and additional information)

C07K 16/24 (2013.01); A61K 38/1866 (2013.01); C07K 14/503 (2013.01); C07K 14/52 (2013.01); C07K 14/8121 (2013.01); C07K 16/22 (2013.01)

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9908522 A1 19990225; AU 8905698 A 19990308; CA 2300964 A1 19990225; CN 1275050 A 20001129; EP 1011328 A1 20000628; EP 1011328 A4 20010516; JP 2001514867 A 20010918

INPADOC legal status


2007-03-23 [REG HK WD] APPLICATIONS WITHDRAWN, DEEMED TO BE WITHDRAWN, OR REFUSED AFTER PUBLICATION IN HONG KONG

- Ref Legal Event Code: WD

- Ref Document Number: 1027715

- Country of Ref Document: HK

2002-01-23 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20010606

2001-05-16 [A4] SUPPLEMENTARY SEARCH REPORT

- Ref Legal Event Code: A4

- Effective date: 20010402

2001-05-16 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2000-06-28 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20000315

2000-06-28 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE