EP 1011330 A1 20000628 - CENTRAL NERVOUS SYSTEM AXON REGENERATION
Title (en)
CENTRAL NERVOUS SYSTEM AXON REGENERATION
Title (de)
REGENERATION VON AXONEN DES ZENTRALNERVENSYSTEMS
Title (fr)
REGENERATION D'AXONES DANS LE SYSTEME NERVEUX CENTRAL
Publication
Application
Priority
- US 9816794 W 19980812
- US 5526897 P 19970813
Abstract (en)
[origin: WO9908533A1] Therapies for the treatment of a variety of central nervous system injuries including acute or chronic spinal cord injury, traumatic brain injury, and white matter stroke involve the administration of rho protein inhibitors to promote axon regeneration. Local administration is employed in typical embodiments, and this may include injection of a recombinant virus that expresses an inhibitor. In one embodiment, the inhibitor is C. botulinium C3 exoenzyme or a chimeric C. botulinum C2/C3 construct expressed in a replication-deficient adeno, adeno-associated, or herpes virus.
IPC 1-7
IPC 8 full level
A61K 38/00 (2006.01); A61K 38/48 (2006.01); A61P 25/00 (2006.01); A61P 25/28 (2006.01); A61P 43/00 (2006.01); C07K 14/33 (2006.01); C12N 5/06 (2006.01); C12N 5/07 (2010.01); C12N 5/079 (2010.01); C12N 9/10 (2006.01); A61K 48/00 (2006.01)
CPC (source: EP)
A61K 38/4893 (2013.01); A61P 25/00 (2017.12); A61P 25/28 (2017.12); A61P 43/00 (2017.12); C07K 14/33 (2013.01); C12N 9/1077 (2013.01); A61K 48/00 (2013.01); C07K 2319/00 (2013.01); C12N 2799/028 (2013.01); Y02A 50/30 (2017.12)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9908533 A1 19990225; AU 735607 B2 20010712; AU 9104298 A 19990308; CA 2300878 A1 19990225; EP 1011330 A1 20000628; EP 1011330 A4 20010516; JP 2001515018 A 20010918
DOCDB simple family (application)
US 9816794 W 19980812; AU 9104298 A 19980812; CA 2300878 A 19980812; EP 98943195 A 19980812; JP 2000509293 A 19980812