Global Patent Index - EP 1011705 A2

EP 1011705 A2 2000-06-28 - CONJUGATES TARGETED TO THE INTERLEUKIN-2 RECEPTOR

Title (en)

CONJUGATES TARGETED TO THE INTERLEUKIN-2 RECEPTOR

Title (de)

KONJUGATE, DIE AUF DEN INTERLEUKIN-2 REZEPTOR ZIELGERICHTET SIND

Title (fr)

CONJUGUES CIBLES APPORTES AU RECEPTEUR DE L'INTERLEUKINE-2

Publication

EP 1011705 A2 (EN)

Application

EP 98939226 A

Priority

  • US 9816290 W
  • US 91404297 A

Abstract (en)

[origin: WO9907324A2] A composition for intracellular delivery of a chemical agent into an interleukin-2-receptor-bearing cell, e.g. an activated T cell, includes a chemical agent and at least two copies of an interleukin-2-receptor-binding and endocytosis-inducing ligand coupled to a water soluble polymer. The ligand binds to a receptor on the interleukin-2-receptor-bearing cell and elicits endocytosis of the composition. The composition also optionally includes a spacer for coupling the chemical agent and the ligand to the polymer. Chemical agents can include cytotoxins, transforming nucleic acids, gene regulators, labels, antigens, drugs, and the like. A preferred water soluble polymer is polyalkylene oxide, such as polyethylene glycol and polyethylene oxide, and activated derivatives thereof. The composition can further comprise a carrier such as another water soluble polymer, liposome, or particulate. Methods of using these compositions for delivering a chemical agent in vivo or in vitro are also disclosed.

IPC 1-7 (main, further and additional classification)

A61K 38/00; A61K 38/04; A61K 38/08

IPC 8 full level (invention and additional information)

A61K 38/00 (2006.01); A61K 45/06 (2006.01); A61K 47/48 (2006.01); A61P 35/02 (2006.01)

CPC (invention and additional information)

A61K 47/48276 (2013.01)

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9907324 A2 19990218; WO 9907324 A3 19990415; AU 8769898 A 19990301; CA 2299368 A1 19990218; EP 1011705 A2 20000628; EP 1011705 A4 20000920; JP 2003516305 A 20030513

INPADOC legal status


2002-10-09 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20020301

2000-09-20 [A4] SUPPLEMENTARY SEARCH REPORT

- Effective date: 20000803

2000-09-20 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A4

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2000-09-20 [RIC1] CLASSIFICATION (CORRECTION)

- Free text: 7A 61K 38/00 A, 7A 61K 38/04 B, 7A 61K 38/08 B, 7A 61K 47/48 B, 7C 07K 7/06 B

2000-06-28 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000217

2000-06-28 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A2

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE