EP 1011705 A2 20000628 - CONJUGATES TARGETED TO THE INTERLEUKIN-2 RECEPTOR
Title (en)
CONJUGATES TARGETED TO THE INTERLEUKIN-2 RECEPTOR
Title (de)
KONJUGATE, DIE AUF DEN INTERLEUKIN-2 REZEPTOR ZIELGERICHTET SIND
Title (fr)
CONJUGUES CIBLES APPORTES AU RECEPTEUR DE L'INTERLEUKINE-2
Publication
Application
Priority
- US 9816290 W 19980805
- US 91404297 A 19970805
Abstract (en)
[origin: WO9907324A2] A composition for intracellular delivery of a chemical agent into an interleukin-2-receptor-bearing cell, e.g. an activated T cell, includes a chemical agent and at least two copies of an interleukin-2-receptor-binding and endocytosis-inducing ligand coupled to a water soluble polymer. The ligand binds to a receptor on the interleukin-2-receptor-bearing cell and elicits endocytosis of the composition. The composition also optionally includes a spacer for coupling the chemical agent and the ligand to the polymer. Chemical agents can include cytotoxins, transforming nucleic acids, gene regulators, labels, antigens, drugs, and the like. A preferred water soluble polymer is polyalkylene oxide, such as polyethylene glycol and polyethylene oxide, and activated derivatives thereof. The composition can further comprise a carrier such as another water soluble polymer, liposome, or particulate. Methods of using these compositions for delivering a chemical agent in vivo or in vitro are also disclosed.
IPC 1-7
IPC 8 full level
A61K 38/00 (2006.01); A61K 45/06 (2006.01); A61K 47/48 (2006.01); A61P 35/02 (2006.01)
CPC (source: EP)
A61K 47/6425 (2017.07); A61P 35/02 (2017.12)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9907324 A2 19990218; WO 9907324 A3 19990415; AU 8769898 A 19990301; CA 2299368 A1 19990218; EP 1011705 A2 20000628; EP 1011705 A4 20000920; JP 2003516305 A 20030513
DOCDB simple family (application)
US 9816290 W 19980805; AU 8769898 A 19980805; CA 2299368 A 19980805; EP 98939226 A 19980805; JP 2000506921 A 19980805