Global Patent Index - EP 1011705 A4

EP 1011705 A4 20000920 - CONJUGATES TARGETED TO THE INTERLEUKIN-2 RECEPTOR

Title (en)

CONJUGATES TARGETED TO THE INTERLEUKIN-2 RECEPTOR

Title (de)

KONJUGATE, DIE AUF DEN INTERLEUKIN-2 REZEPTOR ZIELGERICHTET SIND

Title (fr)

CONJUGUES CIBLES APPORTES AU RECEPTEUR DE L'INTERLEUKINE-2

Publication

EP 1011705 A4 20000920 (EN)

Application

EP 98939226 A 19980805

Priority

  • US 9816290 W 19980805
  • US 91404297 A 19970805

Abstract (en)

[origin: WO9907324A2] A composition for intracellular delivery of a chemical agent into an interleukin-2-receptor-bearing cell, e.g. an activated T cell, includes a chemical agent and at least two copies of an interleukin-2-receptor-binding and endocytosis-inducing ligand coupled to a water soluble polymer. The ligand binds to a receptor on the interleukin-2-receptor-bearing cell and elicits endocytosis of the composition. The composition also optionally includes a spacer for coupling the chemical agent and the ligand to the polymer. Chemical agents can include cytotoxins, transforming nucleic acids, gene regulators, labels, antigens, drugs, and the like. A preferred water soluble polymer is polyalkylene oxide, such as polyethylene glycol and polyethylene oxide, and activated derivatives thereof. The composition can further comprise a carrier such as another water soluble polymer, liposome, or particulate. Methods of using these compositions for delivering a chemical agent in vivo or in vitro are also disclosed.

IPC 1-7

A61K 38/00; A61K 38/04; A61K 38/08; A61K 47/48; C07K 7/06

IPC 8 full level

A61K 38/00 (2006.01); A61K 45/06 (2006.01); A61K 47/48 (2006.01); A61P 35/02 (2006.01)

CPC (source: EP)

A61K 47/6425 (2017.07); A61P 35/02 (2017.12)

Citation (search report)

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9907324 A2 19990218; WO 9907324 A3 19990415; AU 8769898 A 19990301; CA 2299368 A1 19990218; EP 1011705 A2 20000628; EP 1011705 A4 20000920; JP 2003516305 A 20030513

DOCDB simple family (application)

US 9816290 W 19980805; AU 8769898 A 19980805; CA 2299368 A 19980805; EP 98939226 A 19980805; JP 2000506921 A 19980805