Global patent index - EP 1011730 A2

EP 1011730 A2 2000-06-28 - TARGETED ADDITION OF SOLUBLE POLYMERS TO RECOMBINANT PROTEINS

Title (en)

TARGETED ADDITION OF SOLUBLE POLYMERS TO RECOMBINANT PROTEINS

Title (de)

GEZIELTE HINZUFÜGUNG VON WASSERLÖSLICHEN POLYMEREN ZU REKOMBINANTEN PROTEINEN

Title (fr)

APPORT CIBLE DE POLYMERES SOLUBLES A DES PROTEINES DE RECOMBINAISON

Publication

EP 1011730 A2 (EN)

Application

EP 97945549 A

Priority

  • US 9718104 W
  • US 2809196 P

Abstract (en)

[origin: WO9815293A2] Proteins are modified with soluble polymers to change their biological properties, such as to render them less immunogenic and longer-lived in the body. The modification is by a strong, but non-covalent complexation between a metal chelate and an oligohistidine tag which is engineered into the protein. This method of protein modification leads to homogeneous preparations which can be readily prepared in large quantities.

IPC 1-7 (main, further and additional classification)

A61K 47/48

IPC 8 full level (invention and additional information)

A61K 47/48 (2006.01)

CPC (invention and additional information)

A61K 47/48215 (2013.01); A61K 47/4823 (2013.01)

Citation (search report)

See references of WO 9815293A3

Designated contracting state (EPC)

AT CH DE FR GB IT LI

EPO simple patent family

WO 9815293 A2 19980416; WO 9815293 A3 19980618; AU 4672297 A 19980505; EP 1011730 A2 20000628

INPADOC legal status

2001-11-07 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20010505

2000-12-13 [17Q] FIRST EXAMINATION REPORT

- Ref Legal Event Code: 17Q

- Effective date: 20001025

2000-06-28 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 19990409

2000-06-28 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT CH DE FR GB IT LI