EP 1011730 A2 20000628 - TARGETED ADDITION OF SOLUBLE POLYMERS TO RECOMBINANT PROTEINS
Title (en)
TARGETED ADDITION OF SOLUBLE POLYMERS TO RECOMBINANT PROTEINS
Title (de)
GEZIELTE HINZUFÜGUNG VON WASSERLÖSLICHEN POLYMEREN ZU REKOMBINANTEN PROTEINEN
Title (fr)
APPORT CIBLE DE POLYMERES SOLUBLES A DES PROTEINES DE RECOMBINAISON
Publication
Application
Priority
- US 9718104 W 19971007
- US 2809196 P 19961007
Abstract (en)
[origin: WO9815293A2] Proteins are modified with soluble polymers to change their biological properties, such as to render them less immunogenic and longer-lived in the body. The modification is by a strong, but non-covalent complexation between a metal chelate and an oligohistidine tag which is engineered into the protein. This method of protein modification leads to homogeneous preparations which can be readily prepared in large quantities.
IPC 1-7
IPC 8 full level
A61K 47/48 (2006.01)
CPC (source: EP)
A61K 47/60 (2017.07); A61K 47/61 (2017.07)
Citation (search report)
See references of WO 9815293A2
Designated contracting state (EPC)
AT CH DE FR GB IT LI
DOCDB simple family (publication)
WO 9815293 A2 19980416; WO 9815293 A3 19980618; AU 4672297 A 19980505; EP 1011730 A2 20000628
DOCDB simple family (application)
US 9718104 W 19971007; AU 4672297 A 19971007; EP 97945549 A 19971007