EP 1012150 A1 20000628 - HETEROARYLCARBOXAMIDE COMPOUNDS ACTIVE AGAINST PROTEIN TYROSINE KINASE RELATED DISORDERS
Title (en)
HETEROARYLCARBOXAMIDE COMPOUNDS ACTIVE AGAINST PROTEIN TYROSINE KINASE RELATED DISORDERS
Title (de)
HETEROARYLCARBOXAMID-VERBINDUNGEN DIE GEGEN DURCH PROTEIN-TYROSIN-KINASE VERURSACHTE KRANKHEITEN WIRKSAM SIND
Title (fr)
COMPOSES D'HETEROARYLCARBOXAMIDE ACTIFS CONTRE LES ETATS PATHOLOGIQUES LIES AUX PROTEINE TYROSINE KINASES
Publication
Application
Priority
- US 9810174 W 19980518
- US 4708497 P 19970519
- US 4694597 P 19970519
- US 5662397 P 19970820
- US 6159097 P 19971010
Abstract (en)
[origin: WO9852944A1] The present invention relates to novel heteroarylcarboxamides which modulate the activity of protein tyrosine kinases and are expected to be useful in the treatment of abnormal protein tyrosine kinase activity driven disorders, to methods for the treatment of inappropriate FGFR activity related disorders with the heteroarylcarboxamide, N-(4-trifluoromethyl-phenyl)-5-methylisoxazole-4-carboxamide, and to the treatment of solid tumor cancers, especially glioblastoma and astrocytoma, with a combination of a nitrosourea, preferably BCNU (carmustin) and N-(4-trifluoromethyl-phenyl)-5-methylisoxazole-4-carboxamide.
IPC 1-7
IPC 8 full level
C07D 231/12 (2006.01); C07D 261/18 (2006.01); C07D 277/32 (2006.01); C07D 401/12 (2006.01); C07D 413/12 (2006.01)
CPC (source: EP)
C07D 261/18 (2013.01); C07D 277/32 (2013.01); C07D 401/12 (2013.01); C07D 413/12 (2013.01)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9852944 A1 19981126; AR 015685 A1 20010516; AU 7687998 A 19981211; CA 2302438 A1 19981126; EP 1012150 A1 20000628; EP 1012150 A4 20020529
DOCDB simple family (application)
US 9810174 W 19980518; AR P980102308 A 19980519; AU 7687998 A 19980518; CA 2302438 A 19980518; EP 98924794 A 19980518