Global Patent Index - EP 1012155 A4

EP 1012155 A4 2002-11-04 - HUMAN UNCOUPLING PROTEIN 3

Title (en)

HUMAN UNCOUPLING PROTEIN 3

Title (de)

MENSCHLICHES 'UNCOUPLING'-PROTEIN 3

Title (fr)

PROTEINE 3 DE DECOUPLAGE D'ORIGINE HUMAINE

Publication

EP 1012155 A4 (EN)

Application

EP 98923517 A

Priority

  • GB 9716886 A
  • US 9810215 W
  • US 4717997 P
  • US 6914197 P

Abstract (en)

[origin: WO9852958A1] An isolated nucleic acid molecule is disclosed which encodes a novel human uncoupling protein (UCP3), and related recombinant expression vectors, recombinant host cells and substantially purified forms of the UCP3 protein. The isolated nucleic acid and proteins disclosed herein will be useful in methods associated with identifying compounds which modulate energy expenditure and body weight regulation, as well as effecting diseases such as obesity and diabetes as well as mitochondria-associated hypermetabolism. Additionally, the isolated nucleic acids of the present invention are candidates for gene therapy of a mammalian host, including humans.

IPC 1-7 (main, further and additional classification)

C07H 17/00; C12N 1/20; C12N 15/00; C12P 21/06

IPC 8 full level (invention and additional information)

C12N 15/09 (2006.01); A61K 31/7088 (2006.01); A61K 38/00 (2006.01); A61K 48/00 (2006.01); A61P 3/04 (2006.01); A61P 3/10 (2006.01); A61P 43/00 (2006.01); C07K 14/47 (2006.01); C07K 14/575 (2006.01); C12N 1/19 (2006.01); C12N 5/10 (2006.01); C12P 21/06 (2006.01); C12Q 1/68 (2006.01)

CPC (invention and additional information)

C07K 14/5759 (2013.01); C07K 14/47 (2013.01)

Citation (search report)

  • [E] WO 9839432 A1 19980911 - SMITHKLINE BEECHAM PLC [GB], et al
  • [E] WO 9850542 A1 19981112 - NOVARTIS AG [CH], et al
  • [X] BOSS O ET AL: "UNCOUPLING PROTEIN-3: A NEW MEMBER OF THE MITOCHONDRIAL CARRIER FAMILY WITH TISSUE-SPECIFIC EXPRESSION", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 408, no. 1, 1997, pages 39 - 42, XP002067895, ISSN: 0014-5793 & DATABASE SWALLPROT [online] XP002214359, Database accession no. p55916SWALLPROTp55916
  • [PA] MATSUDA J ET AL: "Cloning of rat uncoupling protein-3 and uncoupling protein-2 cDNAs: their gene expression in rats fed high-fat diet", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 418, no. 1-2, 24 November 1997 (1997-11-24), pages 200 - 204, XP004261541, ISSN: 0014-5793 & DATABASE SWALLPROT [online] XP002214361, Database accession no. p56501SWALLPROTp56501
  • [T] YOSHITOMI H ET AL: "Cloning of mouse uncoupling protein 3 cDNA and 5'-flanking region, and its genetic map", GENE, ELSEVIER BIOMEDICAL PRESS. AMSTERDAM, NL, vol. 215, no. 1, July 1998 (1998-07-01), pages 77 - 84, XP004149231, ISSN: 0378-1119
  • See also references of WO 9852958A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

EPO simple patent family

WO 9852958 A1 19981126; CA 2289945 A1 19981126; EP 1012155 A1 20000628; EP 1012155 A4 20021104; JP 2002502240 A 20020122

INPADOC legal status


2005-08-03 [18D] APPLICATION DEEMED TO BE WITHDRAWN

- Effective date: 20050103

2004-08-18 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20040701

2002-12-18 [A4] DESPATCH OF SUPPLEMENTARY SEARCH REPORT

- Effective date: 20021104

2002-11-04 [A4] DESPATCH OF SUPPLEMENTARY SEARCH REPORT

2002-11-04 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A4

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

2000-06-28 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 19991220

2000-06-28 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE