Global Patent Index - EP 1012165 A1

EP 1012165 A1 2000-06-28 - PROCESS FOR THE PREPARATION OF N-METHYL-D-PHENYLALANYL-N- 1- 3- (AMINOIMINOMETHYL)AMINO PROPYL -3,3-DIFLUORO-2-OXOHEXYL -L-PROLINAMIDE

Title (en)

PROCESS FOR THE PREPARATION OF N-METHYL-D-PHENYLALANYL-N- 1- 3- (AMINOIMINOMETHYL)AMINO PROPYL -3,3-DIFLUORO-2-OXOHEXYL -L-PROLINAMIDE

Title (de)

VERFAHREN ZUR HERSTELLUNG VON N-METHYL-D-PHENYLALANYL-N-1-3-(AMINOIMINOMETHYL)AMINO PROPYL -3,3-DIFLUORO-2-OXOHEXYL -L-PROLINAMIDE

Title (fr)

PROCEDE DE PREPARATION DE N-METHYL-D-PHENYLALANYL-N- 1- 3- (AMINOIMINOMETHYL)AMINO PROPYL -3,3-DIFLUORO-2-OXOHEXYL -L-PROLINAMIDE

Publication

EP 1012165 A1 (EN)

Application

EP 97908712 A

Priority

  • US 9702869 W
  • US 62472196 A

Abstract (en)

[origin: WO9735874A1] The present invention relates to a novel process for preparing N-methyl-D-phenylalanyl-N-[1-[3-[(aminoiminomethyl)amino]propyl]-3,3-difluoro-2-oxohexyl]-L-prolinamide or a pharmaceutically acceptable salt therof and to a key intermediate by directly guanylating Dakin-West intermediates.

IPC 1-7 (main, further and additional classification)

C07K 5/06; C07C 277/08

IPC 8 full level (invention and additional information)

C07C 277/08 (2006.01); C07C 279/12 (2006.01); C07K 1/06 (2006.01); C07K 5/06 (2006.01); C07K 5/087 (2006.01)

CPC (invention and additional information)

C07K 5/06191 (2013.01); C07C 277/08 (2013.01)

Citation (search report)

See references of WO 9735874A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

Designated extension state (EPC)

AL LT LV RO SI

EPO simple patent family

WO 9735874 A1 19971002; AR 006366 A1 19990825; AU 2055097 A 19971017; AU 710040 B2 19990909; BR 9708369 A 19990803; CA 2250583 A1 19971002; CA 2250583 C 20030114; CN 1121410 C 20030917; CN 1214691 A 19990421; EP 1012165 A1 20000628; IL 126071 A 20030624; IL 126071 D0 19990509; JP 2000507267 A 20000613; KR 20000004991 A 20000125; NO 984490 A 19980925; NO 984490 D0 19980925; NZ 331432 A 20000327; ZA 9702506 B 19970926

INPADOC legal status


2007-11-14 [RTI1] TITLE (CORRECTION)

- Free text: PROCESS FOR THE PREPARATION OF N-METHYL-D-PHENYLALANYL-N- 1- 3- (AMINOIMINOMETHYL)AMINO PROPYL -3,3-DIFLUORO-2-OXOHEXYL -L-PROLINAMIDE

2006-10-06 [REG HK WD] APPLICATIONS WITHDRAWN, DEEMED TO BE WITHDRAWN, OR REFUSED AFTER PUBLICATION IN HONG KONG

- Document: HK 1027822

2003-12-17 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20030614

2000-06-28 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 19981001

2000-06-28 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2000-06-28 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Free text: AL PAYMENT 19981001;LT PAYMENT 19981001;LV PAYMENT 19981001;RO PAYMENT 19981001;SI PAYMENT 19981001