EP 1012238 A1 20000628 - PEPTIDES AND PEPTIDE-LOADED ANTIGEN PRESENTING CELLS FOR THE ACTIVATION OF CTL
Title (en)
PEPTIDES AND PEPTIDE-LOADED ANTIGEN PRESENTING CELLS FOR THE ACTIVATION OF CTL
Title (de)
PEPTIDE UND MIT PEPTIDEN BELADENE, ANTIGEN PRÄSENTIERENDE ZELLEN FÜR DIE AKTIVIERUNG VON CYTOTOXISCHEN T-ZELLEN
Title (fr)
CELLULES A PEPTIDES OU A ANTIGENES CHARGES DE PEPTIDES
Publication
Application
Priority
- US 9801959 W 19980130
- US 3669697 P 19970131
Abstract (en)
[origin: WO9833888A1] Methods for generating antigen-specific cytotoxic T lymphocytes (CTLs) in vitro are presented in conjuntion with methods for using these CTLs for therapy in vivo. The antigen presenting cells (APCs) used herein notably include dentritic cells pretreated with GM-CSF and IL-4. Antigen-specific CTLs were obtained by incubating CD8 preparations in the presence of APCs that bound desired peptides. IL-7 was generally added at day 1 of the incubation; IL-10 was generally added one day later and during restimulation. The invention also comprises methods for using peptide pulsed dentritic cells to identify novel MHC Class I-restricted tumor antigens and subdominant epitopes.
IPC 1-7
IPC 8 full level
A61K 35/26 (2006.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01); A61P 31/04 (2006.01); A61P 31/10 (2006.01); A61P 31/12 (2006.01); A61P 31/18 (2006.01); A61P 33/06 (2006.01); C12N 5/0783 (2010.01)
CPC (source: EP US)
A61K 39/0011 (2013.01 - US); A61K 39/4615 (2023.05 - EP); A61K 39/4622 (2023.05 - EP); A61K 39/464406 (2023.05 - EP); A61K 39/464486 (2023.05 - EP); A61P 31/04 (2018.01 - EP); A61P 31/10 (2018.01 - EP); A61P 31/12 (2018.01 - EP); A61P 31/18 (2018.01 - EP); A61P 33/06 (2018.01 - EP); C12N 5/0636 (2013.01 - EP); A61K 2039/57 (2013.01 - EP); C12N 2501/23 (2013.01 - EP); C12N 2502/11 (2013.01 - EP); Y02A 50/30 (2018.01 - EP)
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9833888 A1 19980806; AU 6140998 A 19980825; CA 2278189 A1 19980806; EP 1012238 A1 20000628; EP 1012238 A4 20030305; JP 2001509677 A 20010724
DOCDB simple family (application)
US 9801959 W 19980130; AU 6140998 A 19980130; CA 2278189 A 19980130; EP 98906086 A 19980130; JP 53317398 A 19980130