Global Patent Index - EP 1012238 A4

EP 1012238 A4 20030305 - PEPTIDES AND PEPTIDE-LOADED ANTIGEN PRESENTING CELLS FOR THE ACTIVATION OF CTL

Title (en)

PEPTIDES AND PEPTIDE-LOADED ANTIGEN PRESENTING CELLS FOR THE ACTIVATION OF CTL

Title (de)

PEPTIDE UND MIT PEPTIDEN BELADENE, ANTIGEN PRÄSENTIERENDE ZELLEN FÜR DIE AKTIVIERUNG VON CYTOTOXISCHEN T-ZELLEN

Title (fr)

CELLULES A PEPTIDES OU A ANTIGENES CHARGES DE PEPTIDES

Publication

EP 1012238 A4 20030305 (EN)

Application

EP 98906086 A 19980130

Priority

  • US 9801959 W 19980130
  • US 3669697 P 19970131

Abstract (en)

[origin: WO9833888A1] Methods for generating antigen-specific cytotoxic T lymphocytes (CTLs) in vitro are presented in conjuntion with methods for using these CTLs for therapy in vivo. The antigen presenting cells (APCs) used herein notably include dentritic cells pretreated with GM-CSF and IL-4. Antigen-specific CTLs were obtained by incubating CD8 preparations in the presence of APCs that bound desired peptides. IL-7 was generally added at day 1 of the incubation; IL-10 was generally added one day later and during restimulation. The invention also comprises methods for using peptide pulsed dentritic cells to identify novel MHC Class I-restricted tumor antigens and subdominant epitopes.

IPC 1-7

C12N 5/06; C12N 5/08; C12N 9/08

IPC 8 full level

A61K 35/26 (2006.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01); A61P 31/04 (2006.01); A61P 31/10 (2006.01); A61P 31/12 (2006.01); A61P 31/18 (2006.01); A61P 33/06 (2006.01); C12N 5/0783 (2010.01)

CPC (source: EP US)

A61K 39/0011 (2013.01 - US); A61K 39/4615 (2023.05 - EP); A61K 39/4622 (2023.05 - EP); A61K 39/464406 (2023.05 - EP); A61K 39/464486 (2023.05 - EP); A61P 31/04 (2018.01 - EP); A61P 31/10 (2018.01 - EP); A61P 31/12 (2018.01 - EP); A61P 31/18 (2018.01 - EP); A61P 33/06 (2018.01 - EP); C12N 5/0636 (2013.01 - EP); A61K 2039/57 (2013.01 - EP); C12N 2501/23 (2013.01 - EP); C12N 2502/11 (2013.01 - EP); Y02A 50/30 (2018.01 - EP)

Citation (search report)

  • [XDY] BAKKER A B H ET AL: "GENERATION OF ANTIMELANOMA CYTOTOXIC T LYMPHOCYTES FROM HEALTHY DONORS AFTER PRESENTATION OF MELANOMA-ASSOCIATED ANTIGEN-DERIVED EPITOPES BY DENDRITIC CELLS IN VITRO", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 55, no. 22, 15 November 1995 (1995-11-15), pages 5330 - 5334, XP002032191, ISSN: 0008-5472
  • [YDY] YANG GUCHEN ET AL: "In vitro priming of tumor-reactive cytolytic T lymphocytes by combining IL-10 with B7-CD28 costimulation.", JOURNAL OF IMMUNOLOGY, vol. 155, no. 8, 1995, pages 3897 - 3903, XP002220424, ISSN: 0022-1767
  • [PXPY] TSAI V ET AL: "IDENTIFICATION OF SUBDOMINANT CTL EPITOPES OF THE GP 100 MELANOMA-ASSOCIATED TUMOR ANTIGEN BY PRIMARY IN VITRO IMMUNIZATION WITH PEPTIDE-PULSED DENDRITIC CELLS", JOURNAL OF IMMUNOLOGY, THE WILLIAMS AND WILKINS CO. BALTIMORE, US, vol. 158, no. 4, 1997, pages 1796 - 1802, XP000919288, ISSN: 0022-1767
  • [YD] CHEN W-F ET AL: "IL-10 A NOVEL CYTOTOXIC T CELL DIFFERENTIATION FACTOR", JOURNAL OF IMMUNOLOGY, vol. 147, no. 2, 1991, pages 528 - 534, XP002220425, ISSN: 0022-1767
  • [YD] ROMANI N ET AL: "PROLIFERATING DENDRITIC CELL PROGENITORS IN HUMAN BLOOD", JOURNAL OF EXPERIMENTAL MEDICINE, TOKYO, JP, vol. 180, no. 1, 1 July 1994 (1994-07-01), pages 83 - 93, XP000610046, ISSN: 0022-1007
  • [T] KAWASHIMA I ET AL: "IDENTIFICATION OF GP100-DERIVED, MELANOMA-SPECIFIC CYTOTOXIC PRIMARY IN VITRO IMMUNIZATION WITH PEPTIDE-PULSED DENDRITIC CELLS. T-LYMPHOCYTE EPITOPES RESTRICTED BY HLA-A3 SUPERTYPE MOLECULES BY", INTERNATIONAL JOURNAL OF CANCER, NEW YORK, NY, US, vol. 78, no. 4, 1998, pages 518 - 524, XP000917221, ISSN: 0020-7136
  • [AD] BOON T ET AL: "TUMOR ANTIGENS RECOGNIZED BY T LYMPHOCYTES", ANNUAL REVIEW OF IMMUNOLOGY, ANNUAL REVIEWS INC, US, VOL. 12, PAGE(S) 337-365, ISSN: 0732-0582, XP000882320
  • See also references of WO 9833888A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9833888 A1 19980806; AU 6140998 A 19980825; CA 2278189 A1 19980806; EP 1012238 A1 20000628; EP 1012238 A4 20030305; JP 2001509677 A 20010724

DOCDB simple family (application)

US 9801959 W 19980130; AU 6140998 A 19980130; CA 2278189 A 19980130; EP 98906086 A 19980130; JP 53317398 A 19980130