EP 1012269 A2 20000628 - P13 ANTIGENS FROM BORRELIA
Title (en)
P13 ANTIGENS FROM BORRELIA
Title (de)
P13 ANTIGENEN VON BORRELIA
Title (fr)
ANTIGENES P13 PROVENANT DE BORRELIA
Publication
Application
Priority
- DK 104197 A 19970910
- IB 9801424 W 19980904
- US 5903697 P 19970916
Abstract (en)
[origin: WO9912960A2] The invention relates to an isolated nucleic acid fragment which encodes a polypeptide fragment which exhibits a substantial immunological reactivity with a rabbit polyclonal antibody raised against a polypeptide having an apparent molecular weight of 13 kDa as determined by SDS-PAGE followed by vizualization, said polypeptide being derived from Borrelia burgdorferi B313 and being encoded by the nucleotide sequence of SEQ ID NO:18, said rabbit polyclonal antibody exhibiting substantially no immunological reactivity with proteins from at least 95 % of spirochaetes randomly selected from the group consisting of Borrelia hermsii, Borrelia crocidurae, Borrelia anserina, and Borrelia hispanica, and/or hybridizes readily under highly stringent hybridization conditions with a DNA fragment having a nucleotide sequence selected from the group consisting of SEQ ID NO:18, SEQ ID NO:20, and SEQ ID NO:22, or with a DNA fragment complementary thereto, but exhibits no substantial hybridization when the hybridization conditions are highly stringent with genomic DNA from at least 95 % of spirochaetes randomly selected from the group consisting of Borrelia hermsii, Borrelia crocidurae, Borrelia anserina, and Borrelia hispanica. Furthermore, the invention relates to polypeptide fragments, vectors, transformed cells, and cell lines, a method of preparing a polypeptide fragment and, vaccines as well as diagnostic compositions and kits.
IPC 1-7
C12N 15/11; C07K 14/20; C12N 15/62; C12N 15/63; C12Q 1/68; G01N 33/569; A61K 39/002
IPC 8 full level
C07K 14/20 (2006.01); A61K 39/00 (2006.01)
CPC (source: EP)
C07K 14/20 (2013.01); A61K 39/00 (2013.01); C07K 2319/00 (2013.01); Y02A 50/30 (2018.01)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9912960 A2 19990318; WO 9912960 A3 19990527; AU 8881198 A 19990329; CA 2300365 A1 19990318; EP 1012269 A2 20000628
DOCDB simple family (application)
IB 9801424 W 19980904; AU 8881198 A 19980904; CA 2300365 A 19980904; EP 98940504 A 19980904