Global Patent Index - EP 1012287 A1

EP 1012287 A1 2000-06-28 - SYNTHETIC POLYPEPTIDE FOR DIAGNOSING AND TREATING PRION-RELATED DISEASES

Title (en)

SYNTHETIC POLYPEPTIDE FOR DIAGNOSING AND TREATING PRION-RELATED DISEASES

Title (de)

SYNTHETISCHE POLYPEPTIDE ZUR DIAGNOSE UND THERAPIE VON PRIONERKRANKUNGEN

Title (fr)

POLYPEPTIDES SYNTHETIQUES POUR LE DIAGNOSTIC ET LE TRAITEMENT DE MALADIES A PRION

Publication

EP 1012287 A1 (DE)

Application

EP 98951427 A

Priority

  • DE 19741607 A
  • EP 9805924 W

Abstract (en)

[origin: DE19741607A1] A synthetic polypeptide comprising at least one "defined" PrP sequences or sequences derived therefrom that are recognised by PrP(Sc)-binding substances PrP = prion protein; PrP(Sc) = disease-specific isoform of PrP. Independent claims are also included for the following: (1) a pharmaceutical composition for therapy of prion diseases, comprising at least one synthetic polypeptide as above or at least one PrP(Sc)-binding substance that recognises the "defined" sequences; (2) an agent for diagnosis of prion diseases, comprising at least one synthetic polypeptide as above or at least one PrP(Sc)-binding substance that recognises the "defined" sequences; (3) a vaccine for prevention and therapy of prion diseases, comprising at least one synthetic polypeptide as above or at least one PrP(Sc)-binding substance that recognises the "defined" sequences; (4) a DNA molecule coding at least for a synthetic polypeptide as above; (5) a process for producing PrP(Sc)-specific antibodies, comprising immunising nonhuman mammals with at least one polypeptide as above and isolating the resulting antibodies; (6) a method for detecting PrP(Sc)-specific surface sequence regions, comprising incubating a PrP-specific peptide library with PrP(Sc)-binding substances and visualising the binding regions of the peptide library; and (7) use of polypeptides as above in a pharmaceutical or chemical library for the detection of PrP(Sc)-specific agents.

IPC 1-7 (main, further and additional classification)

C12N 15/12; A61K 38/17; A61K 39/395; C07K 14/47; G01N 33/68

IPC 8 full level (invention and additional information)

C07K 14/47 (2006.01); C12N 15/12 (2006.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01)

CPC (invention and additional information)

C07K 14/47 (2013.01); A61K 38/00 (2013.01); A61K 39/00 (2013.01)

Citation (search report)

See references of WO 9915651A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

DE 19741607 A1 19990325; AU 9744898 A 19990412; EP 1012287 A1 20000628; WO 9915651 A1 19990401

INPADOC legal status


2006-04-26 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20051019

2005-07-27 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20050608

2000-06-28 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000411

2000-06-28 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE