EP 1014961 A4 20010411 - IMPROVED TREATMENT OF MIGRAINE HEADACHE
Title (en)
IMPROVED TREATMENT OF MIGRAINE HEADACHE
Title (de)
VERBESSERTER BEHANDLUNG VON MIGRÄNEKOPFSCHMERZEN
Title (fr)
TRAITEMENT AMELIORE CONTRE LA MIGRAINE
Publication
Application
Priority
- US 9720611 W 19971112
- US 74833296 A 19961112
- US 96650697 A 19971110
Abstract (en)
[origin: WO9820870A1] This invention comprises a non-vasoactive, supra-vasoactive syndrome ("SVS") minimized dosage form for treatment of migraine in a human comprising (i) rapid availability metoclopramide in at least about an effective local gastrointestinal amount; (ii) at least one long acting NSAID such as naproxen sodium in a therapeutically effective amount; (iii) wherein said dosage form is a coordinated dosage form; and, (iv) wherein the dosage form is absent 5HT agonist vasoactive agents, and preparation thereof. Acid-base stable dosage forms are noted. This invention further comprises methods of migraine treatment, and methods for rapid introduction of oral NSAID into the small bowel.
IPC 1-7
A61K 31/165; A61K 31/19; A61K 31/42; A61K 31/40; A61K 31/12; A61K 31/195; A61K 31/54; A61P 25/06
IPC 8 full level
A61K 9/30 (2006.01); A61K 9/20 (2006.01); A61K 9/22 (2006.01); A61K 9/24 (2006.01); A61K 9/46 (2006.01); A61K 31/12 (2006.01); A61K 31/122 (2006.01); A61K 31/165 (2006.01); A61K 31/166 (2006.01); A61K 31/19 (2006.01); A61K 31/192 (2006.01); A61K 31/195 (2006.01); A61K 31/196 (2006.01); A61K 31/40 (2006.01); A61K 31/407 (2006.01); A61K 31/42 (2006.01); A61K 31/421 (2006.01); A61K 31/54 (2006.01); A61K 31/5415 (2006.01); A61K 45/00 (2006.01); A61K 47/32 (2006.01); A61K 47/38 (2006.01); A61K 47/46 (2006.01); A61P 25/06 (2006.01)
CPC (source: EP US)
A61K 9/0007 (2013.01 - EP US); A61K 9/2081 (2013.01 - EP US); A61K 9/209 (2013.01 - EP US); A61K 31/166 (2013.01 - EP US); A61K 31/19 (2013.01 - EP US); A61P 25/06 (2017.12 - EP)
Citation (search report)
- [X] CA 2020018 A1 19911228 - SIMMONS DON L [CA]
- [X] US 4235971 A 19801125 - BOXER LAWRENCE [US], et al
- [PX] EP 0774253 A1 19970521 - BOUCHARA SA [FR]
- [X] SAADAH, H.A.: "Abortive migraine therapy with oral naproxen sodium plus metoclopramide plus ergotamine tartrate with caffeine", HEADACHE, vol. 32, no. 2, 1992, pages 95 - 97, XP000974061
- See references of WO 9820870A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9820870 A1 19980522; AT E269071 T1 20040715; AU 5201098 A 19980603; AU 732217 B2 20010412; AU 732217 C 20050915; CA 2269745 A1 19980522; CA 2269745 C 20030729; DE 69729587 D1 20040722; DE 69729587 T2 20050623; DK 1014961 T3 20041025; EP 1014961 A1 20000705; EP 1014961 A4 20010411; EP 1014961 B1 20040616; ES 2222522 T3 20050201; JP 2000507614 A 20000620; JP 2005343906 A 20051215; JP 3759624 B2 20060329; PT 1014961 E 20041029; US 2003040537 A1 20030227; US 6077539 A 20000620; US 6479551 B1 20021112; US 7030162 B2 20060418
DOCDB simple family (application)
US 9720611 W 19971112; AT 97946927 T 19971112; AU 5201098 A 19971112; CA 2269745 A 19971112; DE 69729587 T 19971112; DK 97946927 T 19971112; EP 97946927 A 19971112; ES 97946927 T 19971112; JP 2005255155 A 20050902; JP 52192798 A 19971112; PT 97946927 T 19971112; US 25503602 A 20020926; US 51775100 A 20000303; US 96650697 A 19971110