Global Patent Index - EP 1014973 A4

EP 1014973 A4 2000-09-20 - ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS

Title (en)

ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS

Title (de)

ALPHA-1a-ADRENORECEPTOR ANTAGONISTEN

Title (fr)

ANTAGONISTES DES ADRENORECEPTEURS ALPHA 1a

Publication

EP 1014973 A4 (EN)

Application

EP 98931320 A

Priority

  • GB 9800219 A
  • US 9812573 W
  • US 5013697 P

Abstract (en)

[origin: WO9857632A1] This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as alpha 1a adrenergic receptor antagonists. One application of these compounds is in the treatment of benign prostatic hyperplasia. These compounds are selective in their ability to relax smooth muscle tissue enriched in the alpha 1a receptor subtype without at the same time inducing hypotension. One such tissue is found surrounding the urethral lining. Therefore, one utility of the instant compounds is to provide acute relief to males suffering from benign prostatic hyperplasia, by permitting less hindered urine flow. Another utility of the instant compounds is provided by combination with a human 5-alpha reductase inhibitory compound, such that both acute and chronic relief from the effects of benign prostatic hyperplasia are achieved.

IPC 1-7 (main, further and additional classification)

C07D 263/26; C07D 239/34; A61K 31/415; A61K 31/42; A61K 31/425; A61K 31/505; A61K 31/275; C07D 491/08; C07D 487/04; C07D 233/02; C07D 275/06

IPC 8 full level (invention and additional information)

C07D 233/74 (2006.01); A61K 31/277 (2006.01); A61K 31/40 (2006.01); A61K 31/4166 (2006.01); A61K 31/421 (2006.01); A61K 31/426 (2006.01); A61K 31/428 (2006.01); A61K 31/4439 (2006.01); A61K 31/513 (2006.01); A61P 13/08 (2006.01); A61P 43/00 (2006.01); C07C 255/46 (2006.01); C07C 271/24 (2006.01); C07D 207/24 (2006.01); C07D 207/263 (2006.01); C07D 207/36 (2006.01); C07D 207/404 (2006.01); C07D 263/20 (2006.01); C07D 263/26 (2006.01); C07D 275/06 (2006.01); C07D 277/14 (2006.01); C07D 413/12 (2006.01); C07D 417/12 (2006.01); C07D 487/04 (2006.01); C07D 491/048 (2006.01)

CPC (invention and additional information)

C07D 275/06 (2013.01); C07C 255/46 (2013.01); C07D 263/26 (2013.01); C07C 2601/02 (2017.05); C07C 2601/14 (2017.05); C07C 2603/18 (2017.05)

Citation (search report)

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

EPO simple patent family

WO 9857632 A1 19981223; AU 8147498 A 19990104; CA 2294591 A1 19981223; EP 1014973 A1 20000705; EP 1014973 A4 20000920; JP 2002511086 A 20020409

INPADOC legal status


2001-04-11 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20001021

2000-09-20 [A4] SUPPLEMENTARY SEARCH REPORT

- Effective date: 20000803

2000-09-20 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A4

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

2000-09-13 [RIC1] CLASSIFICATION (CORRECTION)

- Free text: 7C 07D 263/26 A, 7C 07D 239/34 B, 7A 61K 31/415 B, 7A 61K 31/42 B, 7A 61K 31/425 B, 7A 61K 31/505 B, 7A 61K 31/275 B, 7C 07D 491/08 B, 7C 07D 487/04 B, 7C 07D 233/02 B, 7C 07D 275/06 B

2000-07-05 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000118

2000-07-05 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE