Global Patent Index - EP 1015029 A1

EP 1015029 A1 2000-07-05 - COMPOUND INHIBITING PRESENILIN 1 FOR PREPARING A MEDICINE AND A DIAGNOSTIC AGENT

Title (en)

COMPOUND INHIBITING PRESENILIN 1 FOR PREPARING A MEDICINE AND A DIAGNOSTIC AGENT

Title (de)

ZUSAMMENSETZUNG ZUR INHIBIERUNG VON PRESENILIN 1 ZUR HERSTELLUNG EINES MEDIKAMENTS UND EINER DIAGNOSTIZIERAGENZ

Title (fr)

COMPOSE ASSURANT L'INHIBITION DE LA PRESENILINE 1 POUR LA PREPARATION D'UN MEDICAMENT ET AGENT DE DIAGNOSTIC

Publication

EP 1015029 A1 (FR)

Application

EP 98933754 A

Priority

  • FR 9801387 W
  • FR 9711450 A

Abstract (en)

[origin: FR2768346A1] A compound that inhibits: (a) expression of a nucleotide sequence corresponding to all or part of the presenilin 1 gene; or (b) the expression of a nucleotide sequence having at least 90% homology with the sequence of (a); or (c) the activity of the expression product of (a) or (b), is used for the preparation of a medicament. Also claimed are: (1) an agent that inhibits expression of a presenilin 1 gene sequence by activating the p53 and/or p21 metabolic pathway; (2) an agent that activates expression of a presenilin 1 gene sequence by inhibiting the p53 and/or p21 metabolic pathway; (3) a diagnostic agent for detecting and monitoring cancers, comprising a presenilin 1 gene sequence used as a probe or primer; (4) a diagnostic agent for detecting and monitoring cancers, comprising at least one antibody corresponding to the peptide sequence of an expression product as above; (5) a diagnostic agent for detecting and monitoring Alzheimer's disease, comprising a presenilin 1 gene sequence used as a probe or primer; (6) a diagnostic agent for detecting and monitoring Alzheimer's disease, comprising at least one antibody corresponding to the peptide sequence of an expression product as above.

IPC 1-7 (main, further and additional classification)

A61K 39/395; A61K 31/70; C12Q 1/68; G01N 33/577

IPC 8 full level (invention and additional information)

G01N 33/574 (2006.01); A61K 39/395 (2006.01); A61P 25/28 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07K 14/47 (2006.01); C07K 16/18 (2006.01); C12N 15/09 (2006.01); C12N 15/113 (2010.01); C12P 21/08 (2006.01); C12Q 1/68 (2006.01); G01N 33/577 (2006.01); A61K 38/00 (2006.01)

CPC (invention and additional information)

C12N 15/113 (2013.01); C07K 14/4711 (2013.01); C07K 16/18 (2013.01); A61K 38/00 (2013.01)

Citation (search report)

See references of WO 9913908A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

FR 2768346 A1 19990319; FR 2768346 B1 20020419; CA 2304011 A1 19990325; EP 1015029 A1 20000705; JP 2001516568 A 20011002; US 6635483 B1 20031021; WO 9913908 A1 19990325; WO 9913908 A9 19990527; WO 9913908 A9 20000224

INPADOC legal status


2003-07-09 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20030101

2002-08-07 [17Q] FIRST EXAMINATION REPORT

- Ref Legal Event Code: 17Q

- Effective date: 20020621

2001-02-07 [RAP1] TRANSFER OF RIGHTS OF AN EP PUBLISHED APPLICATION

- Owner name: MOLECULAR ENGINES LABORATORIES

- Ref Legal Event Code: RAP1

2000-07-05 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20000403

2000-07-05 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE