EP 1015029 A1 20000705 - COMPOUND INHIBITING PRESENILIN 1 FOR PREPARING A MEDICINE AND A DIAGNOSTIC AGENT
Title (en)
COMPOUND INHIBITING PRESENILIN 1 FOR PREPARING A MEDICINE AND A DIAGNOSTIC AGENT
Title (de)
ZUSAMMENSETZUNG ZUR INHIBIERUNG VON PRESENILIN 1 ZUR HERSTELLUNG EINES MEDIKAMENTS UND EINER DIAGNOSTIZIERAGENZ
Title (fr)
COMPOSE ASSURANT L'INHIBITION DE LA PRESENILINE 1 POUR LA PREPARATION D'UN MEDICAMENT ET AGENT DE DIAGNOSTIC
Publication
Application
Priority
- FR 9801387 W 19980629
- FR 9711450 A 19970915
Abstract (en)
[origin: FR2768346A1] A compound that inhibits: (a) expression of a nucleotide sequence corresponding to all or part of the presenilin 1 gene; or (b) the expression of a nucleotide sequence having at least 90% homology with the sequence of (a); or (c) the activity of the expression product of (a) or (b), is used for the preparation of a medicament. Also claimed are: (1) an agent that inhibits expression of a presenilin 1 gene sequence by activating the p53 and/or p21 metabolic pathway; (2) an agent that activates expression of a presenilin 1 gene sequence by inhibiting the p53 and/or p21 metabolic pathway; (3) a diagnostic agent for detecting and monitoring cancers, comprising a presenilin 1 gene sequence used as a probe or primer; (4) a diagnostic agent for detecting and monitoring cancers, comprising at least one antibody corresponding to the peptide sequence of an expression product as above; (5) a diagnostic agent for detecting and monitoring Alzheimer's disease, comprising a presenilin 1 gene sequence used as a probe or primer; (6) a diagnostic agent for detecting and monitoring Alzheimer's disease, comprising at least one antibody corresponding to the peptide sequence of an expression product as above.
IPC 1-7
IPC 8 full level
A61K 39/395 (2006.01); A61P 25/28 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07K 14/47 (2006.01); C07K 16/18 (2006.01); C12N 15/09 (2006.01); C12N 15/11 (2006.01); C12N 15/113 (2010.01); C12P 21/08 (2006.01); C12Q 1/68 (2006.01); G01N 33/574 (2006.01); G01N 33/577 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP US)
A61P 25/28 (2017.12 - EP); A61P 35/00 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07K 14/4711 (2013.01 - EP US); C07K 16/18 (2013.01 - EP US); C12N 15/113 (2013.01 - EP US); A61K 38/00 (2013.01 - EP US)
Citation (search report)
See references of WO 9913908A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
FR 2768346 A1 19990319; FR 2768346 B1 20020419; CA 2304011 A1 19990325; EP 1015029 A1 20000705; JP 2001516568 A 20011002; US 6635483 B1 20031021; WO 9913908 A1 19990325; WO 9913908 A9 19990527; WO 9913908 A9 20000224
DOCDB simple family (application)
FR 9711450 A 19970915; CA 2304011 A 19980629; EP 98933754 A 19980629; FR 9801387 W 19980629; JP 2000511525 A 19980629; US 38239699 A 19990825