Global Patent Index - EP 1015581 A1

EP 1015581 A1 2000-07-05 - INSECTICIDAL GENE AND PEPTIDE

Title (en)

INSECTICIDAL GENE AND PEPTIDE

Title (de)

INSEKTIZIDES GEN UND PEPTID

Title (fr)

GENE ET PEPTIDE INSECTICIDES

Publication

EP 1015581 A1 (EN)

Application

EP 98902118 A

Priority

  • GB 9800308 W
  • GB 9702189 A
  • GB 9725149 A

Abstract (en)

[origin: WO9833906A1] The present invention relates to FMRF amide type peptides and their non-amidated precursors, to recombinant nucleic acids encoding for such peptides, to the use of these nucleic acids, in forms substantially isolated from other nucleic acid or when incorporated into vectors, to transform organisms in order to render them capable of producing these peptides, to the use of such peptides, nucleic acid and vectors as pesticidal agents, eg. insecticidal, acaricidal and helminthecidal agents and to compositions comprising one or more of these. A peptide or salt thereof comprising an amino acid sequence Pro-Pro-(Xaa<1>)n-Phe-Xaa<2>-Arg-Xaa<3> or a conservatively substituted analogue thereof, wherein the N terminal of said peptide may be free amino or protected amino and the C-terminal of said peptide, which is the C-terminal -Xaa<3> of the above sequence, may consist of that residue with a free carboxylic acid group or with an amidated carboxyl of the formula CONR<1>R<2> wherein R<1> and R<2> are independently selected form hydrogen, alkyl, alkenyl, hydroxyalkyl, alkoxyalkyl and aminoalkyl or together with the nitrogen to which they are attached form a C3-8 heterocyclic ring; wherein Xaa<1> is any amino acid, which is independently selected at each repeat n, and n is an integer from 0 to 10 and Xaa<2> is Met, Val, Ile, Leu, Nle or Phe or a conservatively substituted analogue thereof and Xaa<3> is Phe, Asp or Glu, provided that when the peptide is Ile-Pro-Pro-Gln-Phe-Met-Arg-Phe it is not combined with skin of the frog Hylambates (Kassina maculata) is specifically claimed as are nucleic acids encoding therefor.

IPC 1-7 (main, further and additional classification)

C12N 15/12; A01N 37/44; A61K 39/00; C07K 7/06; C07K 7/08; C12N 15/06

IPC 8 full level (invention and additional information)

A01N 63/02 (2006.01); C07K 14/46 (2006.01); C12N 15/12 (2006.01); A61K 39/00 (2006.01)

CPC (invention and additional information)

C07K 14/463 (2013.01); A01N 63/02 (2013.01); C07K 7/06 (2013.01); A01K 2217/05 (2013.01); A61K 39/00 (2013.01)

Citation (search report)

See references of WO 9833906A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9833906 A1 19980806; AU 5874198 A 19980825; CA 2279579 A1 19980806; EP 1015581 A1 20000705

INPADOC legal status


2004-03-03 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20030902

2000-07-05 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 19990806

2000-07-05 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE