Global patent index - EP 1015600 A1

EP 1015600 A1 2000-07-05 - STATIN PRODUCTION BY FERMENTATION

Title (en)

STATIN PRODUCTION BY FERMENTATION

Title (de)

FERMENTATIVE HERSTELLUNG VON STATIN

Title (fr)

PRODUCTION DE STATINE PAR FERMENTATION

Publication

EP 1015600 A1 (EN)

Application

EP 98945280 A

Priority

  • EP 98945280 A
  • EP 9805362 W
  • EP 97306462 A

Abstract (en)

[origin: WO9910499A1] A one-step biosynthesis process of pravastatin is disclosed. Fungal host cells that can produce compactin are transformed with a polynucleotide that encodes a foreign hydroxylase enzyme which is capable of converting the compactin into pravastatin. This can be cheaper and more efficient than previous two-stage fermentation processes (firstly a fungus to produce compactin, and then bacteria to hydroxylate the compactin to pravastatin).

IPC 1-7 (main, further and additional classification)

C12N 15/53; C12P 17/06; C12P 7/62; C12N 9/02; C12N 15/80; C12N 1/15; A61K 31/215; A61K 31/365

IPC 8 full level (invention and additional information)

A61K 31/215 (2006.01); A61K 31/365 (2006.01); A61K 31/366 (2006.01); C12N 1/15 (2006.01); C12N 9/02 (2006.01); C12N 15/53 (2006.01); C12N 15/80 (2006.01); C12P 7/62 (2006.01); C12P 17/06 (2006.01)

CPC (invention and additional information)

C12N 9/0071 (2013.01); A61K 31/215 (2013.01); A61K 31/366 (2013.01); C12N 15/80 (2013.01); C12P 7/62 (2013.01); C12P 17/06 (2013.01)

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9910499 A1 19990304; AU 9264598 A 19990316; EP 1015600 A1 20000705

INPADOC legal status

2001-01-17 [18D] DEEMED TO BE WITHDRAWN

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- Effective date: 20000323

2000-07-19 [D17P] REQUEST FOR EXAMINATION FILED (DELETED)

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2000-07-19 [DAX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT (TO ANY COUNTRY) DELETED

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2000-07-05 [17P] REQUEST FOR EXAMINATION FILED

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- Effective date: 20000216

2000-07-05 [AK] DESIGNATED CONTRACTING STATES:

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- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2000-07-05 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

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- Free Format Text: AL PAYMENT 20000216;LT PAYMENT 20000216;LV PAYMENT 20000216;MK PAYMENT 20000216;RO PAYMENT 20000216;SI PAYMENT 20000216