Global Patent Index - EP 1015615 A1

EP 1015615 A1 2000-07-05 - TARGETED GENE TRANSFER USING G PROTEIN COUPLED RECEPTORS

Title (en)

TARGETED GENE TRANSFER USING G PROTEIN COUPLED RECEPTORS

Title (de)

GEZIELTER GENTRANSFER MITTELS G-PROTEIN-VERMITTELTENDEN REZEPTOREN

Title (fr)

TRANSFERT GENIQUE CIBLE EMPLOYANT DES RECEPTEURS COUPLES A UNE PROTEINE G

Publication

EP 1015615 A1 (EN)

Application

EP 98931640 A

Priority

  • US 9813336 W
  • US 5084397 P

Abstract (en)

[origin: WO9900511A1] A method of delivering heterologous nucleic acid (e.g., a gene sequence) into a cell comprises attaching a virus containing a heterologous gene sequence to a G protein coupled receptor (i.e., a seven transmembrane receptor such as the P2Y2 receptor). The virus may be attached to the receptor by means of a bridging antibody, or by binding an antibody specific for the receptor with an antibody specific for the virus, wherein the antibody that specifically binds with the receptor and the antibody that specifically binds to the virus are cross-linked. Alternatively, the virus may express a peptide that specifically binds to the receptor. The receptor may be induced to internalize by means of the addition of a ligand known to trigger internalization of the receptor into the cell.

IPC 1-7 (main, further and additional classification)

C12N 15/85; A61K 39/395

IPC 8 full level (invention and additional information)

C12N 15/09 (2006.01); A61K 35/76 (2006.01); A61K 38/00 (2006.01); A61K 39/395 (2006.01); A61K 48/00 (2006.01); C07K 14/72 (2006.01); C07K 16/08 (2006.01); C07K 16/10 (2006.01); C07K 16/28 (2006.01); C12N 15/62 (2006.01); C12N 15/861 (2006.01); C12N 15/87 (2006.01)

CPC (invention and additional information)

C12N 15/86 (2013.01); A61K 48/00 (2013.01); C07K 14/72 (2013.01); C07K 16/08 (2013.01); C07K 16/1018 (2013.01); C12N 15/62 (2013.01); C12N 15/87 (2013.01); C07K 2317/31 (2013.01); C07K 2317/77 (2013.01); C07K 2319/21 (2013.01); C07K 2319/32 (2013.01); C12N 2710/10343 (2013.01); C12N 2710/10345 (2013.01); C12N 2810/60 (2013.01); C12N 2810/80 (2013.01); C12N 2810/851 (2013.01); C12N 2810/859 (2013.01)

Citation (search report)

See references of WO 9900511A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9900511 A1 19990107; AU 8171098 A 19990119; CA 2295315 A1 19990107; EP 1015615 A1 20000705; JP 2002511759 A 20020416

INPADOC legal status


2003-08-06 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20030102

2000-07-05 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 19991230

2000-07-05 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE