EP 1015615 A1 20000705 - TARGETED GENE TRANSFER USING G PROTEIN COUPLED RECEPTORS
Title (en)
TARGETED GENE TRANSFER USING G PROTEIN COUPLED RECEPTORS
Title (de)
GEZIELTER GENTRANSFER MITTELS G-PROTEIN-VERMITTELTENDEN REZEPTOREN
Title (fr)
TRANSFERT GENIQUE CIBLE EMPLOYANT DES RECEPTEURS COUPLES A UNE PROTEINE G
Publication
Application
Priority
- US 9813336 W 19980626
- US 5084397 P 19970626
Abstract (en)
[origin: WO9900511A1] A method of delivering heterologous nucleic acid (e.g., a gene sequence) into a cell comprises attaching a virus containing a heterologous gene sequence to a G protein coupled receptor (i.e., a seven transmembrane receptor such as the P2Y2 receptor). The virus may be attached to the receptor by means of a bridging antibody, or by binding an antibody specific for the receptor with an antibody specific for the virus, wherein the antibody that specifically binds with the receptor and the antibody that specifically binds to the virus are cross-linked. Alternatively, the virus may express a peptide that specifically binds to the receptor. The receptor may be induced to internalize by means of the addition of a ligand known to trigger internalization of the receptor into the cell.
IPC 1-7
IPC 8 full level
A61K 35/76 (2006.01); A61K 38/00 (2006.01); A61K 39/395 (2006.01); A61K 48/00 (2006.01); C07K 14/72 (2006.01); C07K 16/08 (2006.01); C07K 16/10 (2006.01); C07K 16/28 (2006.01); C12N 15/09 (2006.01); C12N 15/62 (2006.01); C12N 15/861 (2006.01); C12N 15/87 (2006.01)
CPC (source: EP)
A61K 48/00 (2013.01); C07K 14/72 (2013.01); C07K 16/08 (2013.01); C07K 16/1018 (2013.01); C12N 15/62 (2013.01); C12N 15/86 (2013.01); C12N 15/87 (2013.01); C07K 2317/31 (2013.01); C07K 2317/77 (2013.01); C07K 2319/21 (2013.01); C07K 2319/32 (2013.01); C12N 2710/10343 (2013.01); C12N 2710/10345 (2013.01); C12N 2810/60 (2013.01); C12N 2810/80 (2013.01); C12N 2810/851 (2013.01); C12N 2810/859 (2013.01)
Citation (search report)
See references of WO 9900511A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9900511 A1 19990107; AU 8171098 A 19990119; CA 2295315 A1 19990107; EP 1015615 A1 20000705; JP 2002511759 A 20020416
DOCDB simple family (application)
US 9813336 W 19980626; AU 8171098 A 19980626; CA 2295315 A 19980626; EP 98931640 A 19980626; JP 50577799 A 19980626