Global patent index - EP 1015633 A1

EP 1015633 A1 2000-07-05 - METHOD AND KIT FOR EARLY DIAGNOSIS OF AUTOIMMUNITY AND LYMPHOMA IN CENTRAL NERVOUS SYSTEM

Title (en)

METHOD AND KIT FOR EARLY DIAGNOSIS OF AUTOIMMUNITY AND LYMPHOMA IN CENTRAL NERVOUS SYSTEM

Title (de)

VERFAHREN UND REAGENTIENSATZ ZUR FRÜHEN ERKENNUNG VON AUTOIMMUNREAKTIONEN UND LYMPHOMA IM ZNS

Title (fr)

PROCEDE ET KIT DE DIAGNOSTIC PRECOCE DE L'AUTO-IMMUNITE ET DU LYMPHOME DANS LE SYSTEME NERVEUX CENTRAL

Publication

EP 1015633 A1 (EN)

Application

EP 98943596 A

Priority

  • CA 9800873 W
  • CA 2216595 A
  • CA 2220245 A

Abstract (en)

[origin: WO9915696A1] The present invention relates to develop a series of B- and T-cell clonality assay kits. The data presented here has shown the importance of the B- and T-cell clonality assay kits in the early diagnosis and differential diagnosis for MS, PCNSL and other neurological diseases. In comparison to current diagnostic technologies (cytology, oligoclonal bands, CT, MRI, and surgical biopsy), the invented technology demonstrates its benefit as a technique which is high sensitive, specific, non-invasive, and economical, and which can be applied to different specimens (CSF cells, surgical biopsy and autopsy). Utilization of this technology to MS study has shown that the B-cell clonal expansion is present in majority of MS patients, which have undergone antigen-driven somatic mutation in the germinal centers of peripheral lymphoid tissues. This finding implicates an important pathogenic pathway for the development of demyelination in CNS of MS. Furthermore, this technology allows the establishment of clonal specific RNA library from pathogenic cells in the CNS of the patients, which is important for further understanding of the role of antigen(s) in the cause of B-cell clonal expansion, and towards to developing antigen specific therapeutic strategy.

IPC 1-7 (main, further and additional classification)

C12Q 1/68

IPC 8 full level (invention and additional information)

C12Q 1/68 (2006.01)

CPC (invention and additional information)

C12Q 1/6883 (2013.01)

Citation (search report)

See references of WO 9915696A1

Designated contracting state (EPC)

AT BE CH DE DK FR GB IE IT LI NL SE

EPO simple patent family

WO 9915696 A1 19990401; AU 9148498 A 19990412; EP 1015633 A1 20000705

INPADOC legal status

2002-10-09 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20020403

2000-07-12 [RIN1] INVENTOR (CORRECTION)

- Ref Legal Event Code: RIN1

- Inventor name: QIN, YUFEN

2000-07-05 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20000406

2000-07-05 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH DE DK FR GB IE IT LI NL SE