EP 1017366 A1 20000712 - SOLID COPRECIPITATES FOR ENHANCED BIOAVAILABILITY OF LIPOPHILIC SUBSTANCES
Title (en)
SOLID COPRECIPITATES FOR ENHANCED BIOAVAILABILITY OF LIPOPHILIC SUBSTANCES
Title (de)
FESTE KOPRÄZIPITATE ZUR VERBESSERTEN BIOVERFÜGBARKEIT LIPOPHILER SUBSTANZEN
Title (fr)
COPRECIPITES SOLIDES AUGMENTANT LA BIODISPONIBILITE DE SUBSTANCES LIPOPHILES
Publication
Application
Priority
- IL 11917696 A 19960901
- US 9715072 W 19970827
- US 83307697 A 19970402
Abstract (en)
[origin: WO9808490A1] Lipophilic active ingredient are co-melted with tocopherol polyethyleneglycol succinate ("TPGS") and a dispersion adjuvant to obtain solid dry coprecipitate compositions suitable as an oral dosage form. The solid TPGS coprecipitates of lipophilic active ingredients show improved drug release in vitro and enhanced oral bioavailability in vivo.
IPC 1-7
IPC 8 full level
A61K 9/14 (2006.01); A61K 9/16 (2006.01); A61K 9/19 (2006.01); A61K 9/20 (2006.01); A61K 9/48 (2006.01); A61K 31/12 (2006.01); A61K 31/138 (2006.01); A61K 31/352 (2006.01); A61K 31/357 (2006.01); A61K 31/4045 (2006.01); A61K 31/7008 (2006.01); A61K 38/00 (2006.01); A61K 38/22 (2006.01); A61K 45/00 (2006.01); A61K 47/14 (2006.01); A61K 47/22 (2006.01); A61K 47/34 (2006.01); A61K 47/44 (2006.01)
CPC (source: EP)
A61K 9/145 (2013.01); A61K 9/146 (2013.01)
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9808490 A1 19980305; AU 4237397 A 19980319; AU 730216 B2 20010301; CA 2264718 A1 19980305; CA 2264718 C 20060530; EP 1017366 A1 20000712; EP 1017366 A4 20060322; JP 2001523221 A 20011120
DOCDB simple family (application)
US 9715072 W 19970827; AU 4237397 A 19970827; CA 2264718 A 19970827; EP 97940639 A 19970827; JP 51187998 A 19970827